Effect of polymer and ion concentration on mechanical and drug release behavior of gellan hydrogels using factorial design,Journal of Polymer Science

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Effect of polymer and ion concentration on mechanical and drug release behavior of gellan hydrogels using factorial design
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2020-04-08 , DOI: 10.1002/pol.20190205
Shashank Shukla _{1,

2} , Joseph Favata ₃ , Vikas Srivastava _{1,

2} , Sina Shahbazmohamadi ₃ , Anubhav Tripathi _{1,

2,

4} , Anita Shukla _{1,

2,

4}

Affiliation

Developing optimized hydrogel products requires an in‐depth understanding of the mechanisms that drive hydrogel tunability. Here, we performed a full 4 × 4 factorial design study investigating the impact of gellan, a naturally derived polysaccharide (1%, 2%, 3%, or 4% w/v) and CaCl₂ concentration (1, 3, 7, or 10 mM) on the viscoelastic, swelling, and drug release behavior of gellan hydrogels containing a model drug, vancomycin. These concentrations were chosen to specifically provide insight into gellan hydrogel behavior for formulations utilizing polymer and salt concentrations expanding beyond those commonly reported by previous studies exploring gellan. With increasing gellan and CaCl₂ concentration, the hydrogel storage moduli (0.1–100 kPa) followed a power‐law relationship and on average these hydrogels had higher liquid absorption capability and greater total drug release over 6 days. We suggest that the effects of gellan and CaCl₂ concentration and their interactions on hydrogel properties can be explained by various phenomena that lead to increased swelling and increased resistance to network expansion.

中文翻译：

因子设计对聚合物和离子浓度对结冷水凝胶力学和药物释放行为的影响

开发优化的水凝胶产品需要深入了解驱动水凝胶可调性的机制。在这里，我们进行了完整的4×4因子设计研究，调查了吉兰糖聚糖，天然衍生多糖（1％，2％，3％或4％w / v）和CaCl ₂浓度（1、3、7 ，或10 mM）关于含有模型药物万古霉素的吉兰糖凝胶的粘弹性，溶胀和药物释放行为。选择这些浓度是为了特别提供对结冷胶水凝胶行为的见解，该配方利用聚合物和盐的浓度扩展到超出先前探索结冷胶的研究通常报道的浓度。随着结冷胶和CaCl _2的增加浓度，水凝胶储能模量（0.1–100 kPa）遵循幂律关系，平均而言，这些水凝胶在6天内具有更高的液体吸收能力和更大的总药物释放量。我们建议，结冷胶和CaCl ₂浓度及其相互作用对水凝胶特性的影响可以通过导致膨胀增加和对网络扩展的抵抗力增加的各种现象来解释。

更新日期：2020-04-08

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