Highly efficient alginate‐based macromolecular photoinitiator for crosslinking and toughening gelatin hydrogels,Journal of Polymer Science

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Highly efficient alginate‐based macromolecular photoinitiator for crosslinking and toughening gelatin hydrogels
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2020-04-09 , DOI: 10.1002/pol.20200138
Xing Huang _{1,

2} , Yuxi Zhang ₁ , Feng Li ₃ , Jun Zhang ₃ , Yuhua Dai ₃ , Mengquan Shi ₁ , Yuxia Zhao _{1,

2}

Affiliation

Constructing gelatin hydrogels through photopolymerization is getting increasingly attractive due to their excellent biocompatibility and unparalleled flexibility in fabricating complex structures. In this study, an alginate‐based macromolecular photoinitiator (Alg‐2959) is synthesized by grafting Irgacure2959, a widely used hydrophilic small molecular photoinitiator, onto the framework of alginate. The characterization of Alg‐2959 is carried out by ¹H nuclear magnetic resonance (¹HNMR), Fourier infrared spectroscopic (FTIR), Thermogravimetric analysis (TGA), and UV–Vis absorption spectrum. It is shown that Alg‐2959 can induce the polymerization of acrylate monomer poly(ethylene glycol) diacrylate (PEGDA400) and glycidyl methacrylate modified gelatin (Gel‐GM) with similar initiation efficiency as Irgacure2959. Compared with the pure hydrogels prepared using Irgacure2959, the hybrid hydrogels containing Alg‐2959 can be further crosslinked by Ca²⁺ to form the double‐network hydrogels, which exhibit enhanced toughness and elasticity. In addition, due to the introduction of alginate, the migration stability of Alg‐2959 in the hydrogel networks is significantly improved compared with Irgacure2959. These results indicate the great potential of Alg‐2959 in preparing biocompatible and resilient photopolymers.

中文翻译：

高效的基于藻酸盐的高分子光引发剂，用于交联和增韧明胶水凝胶

通过光聚合反应构建明胶水凝胶，由于其出色的生物相容性和在制造复杂结构方面的无与伦比的灵活性而变得越来越有吸引力。在这项研究中，通过将广泛使用的亲水性小分子光引发剂Irgacure2959嫁接到藻酸盐的骨架上，合成了基于藻酸盐的大分子光引发剂（Alg-2959）。Alg-2959的表征是通过¹ H核磁共振（¹HNMR），傅立叶红外光谱（FTIR），热重分析（TGA）和UV-Vis吸收光谱。结果表明，Alg-2959可以引发丙烯酸酯单体聚（乙二醇）二丙烯酸酯（PEGDA400）和甲基丙烯酸缩水甘油酯改性的明胶（Gel-GM）的聚合，其引发效率与Irgacure2959相似。与使用Irgacure2959制备的纯水凝胶相比，含Alg-2959的杂化水凝胶可以通过Ca ²⁺进一步交联。形成具有增强的韧性和弹性的双网络水凝胶。此外，由于引入了藻酸盐，与Irgacure2959相比，Alg-2959在水凝胶网络中的迁移稳定性得到了显着改善。这些结果表明，Alg-2959在制备生物相容性和弹性光敏聚合物方面具有巨大潜力。

更新日期：2020-04-09

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