Synthesis and characterization of hydrogels containing redox‐responsive 2,2,6,6‐tetramethylpiperidinyloxy methacrylate and thermoresponsive N‐isopropylacrylamide,Journal of Polymer Science

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Synthesis and characterization of hydrogels containing redox‐responsive 2,2,6,6‐tetramethylpiperidinyloxy methacrylate and thermoresponsive N‐isopropylacrylamide
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2020-04-25 , DOI: 10.1002/pol.20200172
Miriam Khodeir ₁ , He Jia ₁ , Sayed Antoun ₂ , Christian Friebe ₃ , Ulrich S. Schubert ₃ , Yan Lu _{4,

5} , Evelyne Van Ruymbeke ₁ , Jean‐François Gohy ₁

Affiliation

Smart hydrogels containing 2,2,6,6‐tetramethylpiperidinoxy methacrylate (TEMPO) and N‐isopropylacrylamide (NIPAM) that undergo reversible redox behavior are prepared and investigated. Several polymer networks are first prepared by free‐radical copolymerization of varying amounts of TEMPO, NIPAM, and a crosslinker (diethylene glycol diacrylate) and subsequently swelled with water to lead to hydrogels. In order to investigate the effects of the redox activity of TEMPO units and of the lower critical solution temperature of NIPAM on the hydrogel properties, a study of the swelling ratio of the polymer networks in distilled water at different temperatures is performed for the two forms of TEMPO, the reduced (TEMPO) and oxidized (TEMPO⁺) one. Moreover, the rheological properties are also measured for both hydrogel forms. Finally, the encapsulation abilities of the oxidized hydrogels are demonstrated via electrostatic interactions between positively charged TEMPO⁺ units and negatively charged guest molecules, supporting future application of our system in the biomedical and environmental fields.

中文翻译：

含氧化还原反应性2,2,6,6-四甲基哌啶基氧基甲基丙烯酸酯和热反应性N-异丙基丙烯酰胺的水凝胶的合成与表征

制备并研究了包含2,2,6,6-甲基丙烯酸四甲基哌啶氧基酯（TEMPO）和N-异丙基丙烯酰胺（NIPAM）的可逆氧化还原行为的智能水凝胶。首先通过不同数量的TEMPO，NIPAM和交联剂（二甘醇二丙烯酸二酯）的自由基共聚反应制备几种聚合物网络，然后用水溶胀形成水凝胶。为了研究TEMPO单元的氧化还原活性和NIPAM的较低临界溶液温度对水凝胶性能的影响，针对两种形式的水在不同温度下蒸馏水中聚合物网络的溶胀率进行了研究。 TEMPO，还原的（TEMPO）和氧化的（TEMPO ⁺）一。此外，还测量了两种水凝胶形式的流变性质。最后，通过带正电荷的TEMPO ⁺单元与带负电荷的客体分子之间的静电相互作用，证明了氧化水凝胶的包封能力，支持了我们系统在生物医学和环境领域的未来应用。

更新日期：2020-04-25

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