The gold standard for bladder regeneration in end‐stage bladder disease is the use of intestinal tissue, which is however associated with significant long‐term complications. Our study aims to bioengineer functional detrusor muscle combining bladder smooth muscle cells (SMC) and SMC‐like adipose‐derived stem cells (pADSC) in compressed collagen (CC) hydrogels and to investigate biocompatibility and tissue regeneration of such detrusor‐equivalents in a rat detrusorectomy model.

中文翻译：

---

使用富含细胞的压缩胶原水凝胶进行逼尿肌生物工程。

终末期膀胱疾病中膀胱再生的金标准是使用肠组织，然而这与显着的长期并发症有关。我们的研究旨在在压缩胶原 (CC) 水凝胶中结合膀胱平滑肌细胞 (SMC) 和 SMC 样脂肪干细胞 (pADSC) 对功能性逼尿肌进行生物工程设计，并研究此类逼尿肌等价物在大鼠中的生物相容性和组织再生逼尿肌切除模型。