Vascular implant interventional medical catheter will contact with blood firstly after implantation. The anticoagulation and antibacterial functions of this device will determine the success or failure. Copper (Cu) has been verified to possess multi‐biofunctions, but it was challenging to add the Cu metal to most materials. Take advantage of its functionality; Cu has been grafted on the material surface to improve the anticoagulation function and accelerate endothelialization. In this study, a Cu‐bearing chitosan coating was prepared on the catheter to endow the anticoagulation and anti‐infection functions. Besides, properties characterization and functional evaluation of the coated medical catheter were investigated. Dynamic blood clotting and platelet adhesion tests were carried out to evaluate the anticoagulation property. Besides this, the antibacterial test was used to estimate the anti‐infection function. The surface energy and Cu ions release from the coating were detected and calculated by contact angles and immersion tests, respectively. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR) and X‐ray photoelectron spectroscopy (XPS) revealed that Cu ions were grafted in the chitosan coating. Thermogravimetric analysis (TA) result showed the concentration of Cu ions in the coating. The results of dynamic blood clotting, platelet adhesion, and antibacterial tests revealed that Cu grafted in chitosan would improve the blood compatibility and anti‐infection property. The surface properties and Cu ions release behavior of Cu‐bearing coating revealed the reasons for multi‐biofunctions. This study indicated that the Cu‐bearing chitosan coating could endow the vascular implant interventional device anticoagulation and anti‐infection functions, which has excellent potential for clinical application.

中文翻译：

---

血管植入物介入医疗导管抗凝抗菌功能涂层[J].

血管植入介入医疗导管植入后首先会接触血液。该装置的抗凝和抗菌功能将决定成败。铜 (Cu) 已被证实具有多种生物功能，但将铜金属添加到大多数材料中具有挑战性。利用它的功能；Cu已接枝在材料表面，以提高抗凝功能并加速内皮化。在这项研究中，在导管上制备了含铜壳聚糖涂层，以赋予其抗凝和抗感染功能。此外，还研究了涂层医用导管的性能表征和功能评价。进行动态凝血和血小板粘附试验以评价抗凝性能。除此以外，抗菌试验用于评估抗感染功能。分别通过接触角和浸没试验检测和计算涂层的表面能和铜离子释放。衰减全反射傅里叶变换红外光谱 (ATR-FTIR) 和 X 射线光电子能谱 (XPS) 的结果表明，Cu 离子接枝在壳聚糖涂层中。热重分析 (TA) 结果显示了涂层中 Cu 离子的浓度。动态凝血、血小板粘附和抗菌试验的结果表明，在壳聚糖中接枝铜可提高血液相容性和抗感染性能。含铜涂层的表面性质和铜离子释放行为揭示了多种生物功能的原因。