Iridium‐Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols Using MaxPHOX Ligands: Experimental and Theoretical Study,ChemCatChem

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Iridium‐Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols Using MaxPHOX Ligands: Experimental and Theoretical Study
ChemCatChem ( IF 3.8 ) Pub Date : 2020-05-18 , DOI: 10.1002/cctc.202000442
Albert Cabré _{1,

2} , Martí Garçon _{1,

2} , Albert Gallen ₃ , Lorenzo Grisoni ₁ , Arnald Grabulosa _{3,

4} , Xavier Verdaguer _{1,

2} , Antoni Riera _{1,

2}

Affiliation

The asymmetric isomerization of primary allylic alcohols to chiral aldehydes using iridium‐catalysts bearing P,N‐MaxPHOX ligands has been studied. These catalysts can be fine‐tuned as they present three different stereogenic centers to modulate both the reactivity and enantioselectivity of a family of different substrates. The experimental part is supported by a DFT study of the reaction mechanism, which provides new insights into the key steps of this transformation.

中文翻译：

MaxPHOX配体的铱催化伯烯丙醇的不对称异构化：实验和理论研究

研究了使用带有P，N- MaxPHOX配体的铱催化剂将伯烯丙基醇不对称异构化为手性醛。可对这些催化剂进行微调，因为它们具有三个不同的立体异构中心，可调节一系列不同底物的反应性和对映选择性。实验部分得到了反应机理的DFT研究的支持，该研究为这种转化的关键步骤提供了新的见解。

更新日期：2020-05-18

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