Cooperative Ni/Cu-Catalyzed Asymmetric Propargylic Alkylation of Aldimine Esters.,Angewandte Chemie International Edition

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Cooperative Ni/Cu-Catalyzed Asymmetric Propargylic Alkylation of Aldimine Esters.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-05-18 , DOI: 10.1002/anie.202005019
Lingzi Peng ₁ , Zhuozhuo He ₁ , Xianghong Xu ₁ , Chang Guo ₁

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A novel Ni/Cu dual catalysis gives rise to fundamentally new cooperative reactivity and enables the regio‐ and enantioselective propargylic alkylation reaction. A diverse set of α‐quaternary propargylated amino ester derivatives were synthesized in good yields with excellent enantioselectivity (up to 99 % ee ). This work highlights the power of cooperative catalysis, which can be expected to have broad implications in homogeneous catalysis beyond the highly valuable synthetic intermediates.

中文翻译：

Ni / Cu催化的Aldimine酯的不对称炔丙基炔化反应。

一种新颖的镍/铜双重催化作用从根本上产生了新的协同反应性，并使区域和对映选择性炔丙基烷基化反应成为可能。以高收率和优异的对映选择性（高达99％ee）合成了多种多样的α-季炔丙基氨基酯衍生物。这项工作强调了协同催化的力量，可以期望它对均相催化具有广泛的意义，而不仅仅是有价值的合成中间体。

更新日期：2020-05-18

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