Iodine Catalysis for C(sp3 )-H Fluorination with a Nucleophilic Fluorine Source.,Angewandte Chemie International Edition

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Iodine Catalysis for C(sp3 )-H Fluorination with a Nucleophilic Fluorine Source.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-05-18 , DOI: 10.1002/anie.202004902
Daniel Bafaluy ₁ , Zoritsa Georgieva ₁ , Kilian Muñiz ₁

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Iodine catalysis was developed for aliphatic fluorination through light‐promoted homolytic C−H bond cleavage. The intermediary formation of amidyl radicals enables selective C−H functionalization via carbon‐centered radicals. For the subsequent C−F bond formation, previous methods have typically been limited by a requirement for electrophilic fluorine reagents. We here demonstrate that the intermediary instalment of a carbon–iodine bond sets the stage for an umpolung, thereby establishing an unprecedented nucleophilic fluorination pathway.

中文翻译：

亲核性氟源对C（sp3）-H氟化的碘催化。

碘催化是通过光促进的均相C H键裂解来实现脂肪族氟化的。酰胺基自由基的中间形成可通过以碳为中心的自由基选择性地进行CH官能化。对于随后的CF键形成，以前的方法通常受到对亲电子氟试剂的要求的限制。我们在这里证明，碳碘键的中间部分为蛋白螯合奠定了基础，从而建立了前所未有的亲核氟化途径。

更新日期：2020-05-18

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