Background

Modern surgeries have advanced toward personalized minimal-invasive treatments with a high rate of clinical healing that facilitates the regeneration of tissues. One of the leading approaches to deliver endogenous plasma- and platelet-derived growth factors is the plasma rich in growth factors (PRGF). This narrative review determines the effects of using PRGF in different oral surgical procedures including alveolar ridge augmentation, socket preservation, sinus floor augmentation and periodontal regeneration.

Methods

For this narrative review, a literature search was conducted using PubMed and Researchgate. A combination of the following text words was used to maximize search specificity and sensitivity: “platelet-rich plasma”, “PRP”, “PRGF”, “Platelet-rich growth factor”, “socket preservation”, “Extraction”, “infra-bony pockets”, “sinus floor augmentation”, “randomized clinical controlled trials”, “Alveolar osteitis”, “Periodontal regeneration”, “guided bone regeneration”, “guided tissue regeneration”.

Results

Investigations have generally agreed that PRGF can promote and accelerate the healing process. PRGF optimizes the patient's quality of life by reducing pain, swelling and inflammation rate and also accelerates regeneration of soft tissue and bone tissue regeneration as well.

Conclusions

There is increasing evidence to support the use of PRGF in oral surgical procedures in order to improve the healing processes of the oral soft and hard tissues.

中文翻译：

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富含生长因子的血浆（PRGF）在引导的组织再生和引导的骨再生中的使用。人类组织学，免疫组织化学，组织形态学，放射学和临床结果的综述。

背景

现代外科手术已经朝着具有高临床愈合率，促进组织再生的个性化微创治疗发展。递送内源性血浆和血小板衍生的生长因子的主要方法之一是富含生长因子（PRGF）的血浆。该叙述性综述确定了在不同的口腔外科手术程序中使用PRGF的效果，包括牙槽增高，牙槽窝保存，窦底增高和牙周再生。

方法

对于这篇叙述性评论，使用PubMed和Researchgate进行了文献检索。使用以下文字的组合来最大程度地提高搜索的特异性和敏感性：“富含血小板的血浆”，“ PRP”，“ PRGF”，“富含血小板的生长因子”，“保护套”，“提取物”，“红外线”骨袋”，“窦底隆起”，“随机临床对照试验”，“牙槽骨炎”，“牙周再生”，“引导骨再生”，“引导组织再生”。

结果

研究普遍认为PRGF可以促进和加速愈合过程。PRGF通过减轻疼痛，肿胀和发炎率来优化患者的生活质量，还可以加速软组织的再生和骨组织的再生。

结论

越来越多的证据支持在口腔外科手术中使用PRGF，以改善口腔软组织和硬组织的愈合过程。