An efficient stereoselective synthesis of (−)-protulactone A was established in 9 steps and 14.7% overall yields using d-mannose as starting material. The key steps of our synthesis involved one-pot deprotection/lactonization/Michael addition reaction/acetalization and 1, 3-chelated controlled stereoselective addition.

中文翻译：

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（-）-丙内酯A的立体选择性合成

以d-甘露糖为起始原料，通过9个步骤建立了有效的立体选择性合成（-）-丙内酯A，总产率为14.7％。我们合成的关键步骤涉及一锅脱保护/内酰胺化/迈克尔加成反应/缩醛化和1，3螯合的受控立体选择性加成。