Glioblastoma multiforme (GBM) is the most malignant astrocytoma, the main treatments consist of surgical resection followed by radiotherapy and chemotherapy. Patients, after diagnosed, have a survival rate of one year. GBM cells have an invasive, proliferative and migratory characteristic, also they do not respond properly for usual cancer treatment (radiotherapy, chemotherapy). Fatty acids have been studied as an adjuvant cancer treatment in breast, colorectal and GBM. The fatty acid can alter tumoural cell metabolism causing a modification of eicosanoids production. This study has observed some cellular aspects modified by fatty acid treatment in vitro, using GBM cells (human and rat). Modifications in cell behaviour were analyzed like cell proliferation, apoptosis, migration and invasion cell capacity after treatment with fatty acid (gamma-linolenic acid). The treatment suggested in this study showed an increased number of apoptotic cells and a decreased number of proliferative and migratory cells. These data recognize that gamma-linolenic acid could be used as an alternative treatment for glioblastoma.

多形性胶质母细胞瘤（GBM）是恶性程度最高的星形细胞瘤，主要治疗方法是手术切除，然后是放疗和化疗。患者确诊后，存活率可达一年。GBM 细胞具有侵袭性、增殖性和迁移性特征，而且它们对通常的癌症治疗（放射疗法、化学疗法）也没有适当的反应。脂肪酸已被研究作为乳腺癌、结肠直肠癌和 GBM 的辅助癌症治疗。脂肪酸可以改变肿瘤细胞代谢，导致类二十烷酸产量的改变。这项研究观察到了体外脂肪酸处理改变的一些细胞方面，使用 GBM 细胞（人和大鼠）。在用脂肪酸（γ-亚麻酸）处理后分析细胞行为的改变，如细胞增殖、凋亡、迁移和侵袭细胞能力。本研究中建议的治疗显示凋亡细胞数量增加，增殖和迁移细胞数量减少。这些数据表明，γ-亚麻酸可用作胶质母细胞瘤的替代疗法。