Background

Aluminium is an environmental neurotoxin to which human beings are extensively exposed. However, the molecular mechanism of aluminium toxicity remains unclear.

Methods

The changes in cognitive function of aluminum exposed workers under long-term occupational exposure were evaluated, and the relationship between cognitive changes, plasma memory related BDNF and EGR1 protein expression, and variations of epigenetic markers H3K4me3, H3K9me2, H3K27me3 expression levels in blood was explored.

Results

MMSE, DSFT, DST scores in cognitive function and the levels of plasma BDNF and EGR1 protein expression decreased with the increase of blood aluminum level. H3K4me3, H3K9me2, H3K27me3 expression levels in peripheral blood lymphocytes of aluminum exposed workers were statistically different (all P<0.05). H3K4me3, H3K9me2 and H3K27me3 expression levels in lymphocytes were correlated with blood aluminum level. BDNF, EGR1 protein level and H3K4me3, H3K9me2, H3K27me3 expression levels have different degrees of correlation. There was a linear regression relationship between plasma BDNF, H3K4me3 and H3K9me2. H3K9me2 had a greater effect on BDNF than H3K4me3. There is a linear regression relationship between EGR1, H3K4me3 and H3K27me3, and the influence of H3K4me3 on EGR1 is greater than that of H3K27me3 on EGR1.

Conclusion

Alummnum may regulate the expression of BDNF and EGR1 by regulating H3K4me3, H3K27me3 and H3K9me2, and affect the cognitive function of workers by affecting the expression of BDNF and EGR1.

中文翻译：

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职业铝暴露与通过甲基化修饰组蛋白赖氨酸之间的关系。

背景

铝是人类广泛接触的环境神经毒素。但是，铝毒性的分子机制仍不清楚。

方法

评估了长期职业暴露下铝暴露工人的认知功能变化，并探讨了认知变化，血浆记忆相关BDNF和EGR1蛋白表达与血液中表观遗传标志物H3K4me3，H3K9me2，H3K27me3表达水平之间的关系。 。

结果

MMSE，DSFT，DST认知功能评分以及血浆BDNF和EGR1蛋白表达水平随血液铝水平的升高而降低。铝暴露工人外周血淋巴细胞中H3K4me3，H3K9me2，H3K27me3表达水平有统计学差异（均P < 0.05）。淋巴细胞中H3K4me3，H3K9me2和H3K27me3的表达水平与血铝水平相关。BDNF，EGR1蛋白水平与H3K4me3，H3K9me2，H3K27me3表达水平具有不同的相关程度。血浆BDNF，H3K4me3和H3K9me2之间存在线性回归关系。H3K9me2对BDNF的影响大于H3K4me3。EGR1，H3K4me3和H3K27me3之间存在线性回归关系，H3K4me3对EGR1的影响大于H3K27me3对EGR1的影响。

结论

铝可能通过调节H3K4me3，H3K27me3和H3K9me2来调节BDNF和EGR1的表达，并通过影响BDNF和EGR1的表达来影响工人的认知功能。