AIM Ischemic stroke (IS) is multifactorial disease and therefore different genes and proteins play a role in its development. Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. The aim of this study was to investigate Hp genetic variants in patients with carotid atherosclerotic lesions and IS. MATERIAL AND METHODS A total of 121 subjects with IS participated in the study, 81 male and 40 female. RESULTS Among 121 patients with IS, 79 had diffuse atherosclerotic plaques and stenosis. Hp genotype was statistically significantly associated with CDFI neck carotid artery stenosis findings (p=0.006). Patients with Hp1-2 genotype had statistically significantly larger odds for atherosclerotic changes compared to those with Hp1-1 genotype, as well as those with Hp2-2 genotype. CONCLUSION This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare.

中文翻译：

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缺血性中风患者的肝炎血红蛋白基因型2-2。

AIM缺血性中风（IS）是多因素疾病，因此不同的基因和蛋白质在其发展中起作用。肝红蛋白（Hp）去除游离的血红蛋白，并防止铁引起的氧化损伤，炎症反应，动脉粥样硬化和脑血管疾病。这项研究的目的是调查颈动脉粥样硬化病变和IS患者的Hp基因变异。材料与方法共有121位IS患者参加了这项研究，其中81位男性和40位女性。结果在121名IS患者中，有79名患有弥漫性动脉粥样硬化斑块和狭窄。Hp基因型与CDFI颈颈动脉狭窄的发现有统计学意义（p = 0.006）。与Hp1-1基因型的患者相比，Hp1-2基因型的患者发生动脉粥样硬化改变的几率在统计学上显着更大，以及具有Hp2-2基因型的人。结论本研究表明IS患者Hp2-2基因型与动脉粥样硬化相关，表明Hp2-2基因型是精密医学和个性化医疗的遗传生物标记。