Tunicyclin L, a cyclic peptide from Psammosilene tunicoides: Isolation, characterization, conformational studies and biological activity.,Fitoterapia

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Tunicyclin L, a cyclic peptide from Psammosilene tunicoides: Isolation, characterization, conformational studies and biological activity.
Fitoterapia ( IF 2.5 ) Pub Date : 2020-05-17 , DOI: 10.1016/j.fitote.2020.104628
Yinhuan Hou ₁ , Mengyue Wang ₁ , Chongzhi Sun ₁ , Chongsheng Peng ₁ , Ying Zhang ₁ , Xiaobo Li ₁

Affiliation

Tunicyclin L (1), cyclo (L-Pro1-Gly-L-Phe1-L-Ile-L-Pro2-L-Phe -L-Thr-L-Val), and 11 known compounds, including one cyclic peptide (2), eight carboline alkaloids (3-10), one lignan (11) and one flavone (12) were isolated from the roots of Psammosilene tunicoides. Their structures were elucidated on the basis of extensive UV, IR, MS, NMR spectroscopic data and comparison with literature. Single-crystal X-ray diffraction results revealed the stereochemistry of the 24-membered ring cyclic peptide (1). Among these known compounds, compound 6 was found to be a new natural product, and compounds 3, 4, and 11 were isolated from this plant for the first time. Five compounds (1, 3, 4, 7, and 9) showed moderate anti-acetylcholinesterase (AChE) activity.

中文翻译：

Tunicyclin L，一种来自Psammosilene tunicoides的环肽：分离，表征，构象研究和生物学活性。

Tunicyclin L（1），环（L-Pro1-Gly-L-Phe1-L-Ile-L-Pro2-L-Phe -L-Thr-L-Val）和11种已知化合物，包括一个环肽（2 ），从Psammosilene tunicoides的根中分离出八种碳氢化合物生物碱（3-10），一种木脂素（11）和一种黄酮（12）。根据广泛的UV，IR，MS，NMR光谱数据并与文献比较，阐明了它们的结构。X射线单晶衍射结果揭示了24元环环肽（1）的立体化学。在这些已知化合物中，化合物6被发现是一种新的天然产物，化合物3、4和11首次从该植物中分离出来。五个化合物（1、3、4、7和9）显示出中等的抗乙酰胆碱酯酶（AChE）活性。

更新日期：2020-05-17

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