Drug Discovery Today ( IF 6.5 ) Pub Date : 2020-05-18 , DOI: 10.1016/j.drudis.2020.05.006 Zhongjian Chen 1 , Jingjing He 2 , Jianping Qi 3 , Quangang Zhu 1 , Wei Wu 3 , Yi Lu 3
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Microneedles (MNs) are a self-administrable and painless alternative to hypodermic needles for bolus drug delivery. Sustained drug release is the preferable drug delivery method because it reduces the chemical burden in patients and can deliver therapeutics that require long-term exposure. Here, we review recent advances in long-acting MNs, summarizing polymers used to fabricate long-acting MNs and mechanisms controlling drug release. We also introduce novel designs of separable needles to achieve implantable tips and bioinspired needles for enhanced skin adhesion, as well as strategies using the back layer as a drug reservoir.
中文翻译：
长效微针：最先进技术的进展报告。
微针 (MN) 是一种可自我给药且无痛的替代皮下注射针的药物，可用于推注给药。持续药物释放是优选的药物递送方法，因为它减少了患者的化学负担并且可以递送需要长期暴露的治疗剂。在这里，我们回顾了长效 MNs 的最新进展，总结了用于制造长效 MNs 的聚合物和控制药物释放的机制。我们还介绍了可分离针头的新颖设计，以实现可植入尖端和仿生针头以增强皮肤粘附，以及使用背层作为药物库的策略。
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