Background

The T2 Candida Panel (T2CP) bodes high sensitivity and specificity to detect candidemia, enabling providers to make quick therapy decisions and possibly decrease mortality. However, utilization in practice and clinical application remains to be evaluated.

Objectives

To evaluate the overall provider-utilization of the T2CP at a large community hospital.

Methods

This single center, retrospective, observational study compared antifungal management in all patients with positive or negative T2CP. Additional endpoints included patient-specific variables influencing antifungal management decisions.

Results

Six hundred twenty-eight T2CP results were evaluated. Antifungal optimization occurred in 54% of patients who had antifungal orders at the time of T2CP test. Antifungal therapy was avoided in 60.4% of negative cases. Patients with negative T2CP had significantly fewer days of therapy compared to positive tests.

Conclusions

Although the T2CP led to fewer days of antifungal therapy with negative tests, many opportunities for improvement in antifungal stewardship were identified, specifically, with negative tests.

中文翻译：

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大型社区医院中快速念珠菌专家组对抗真菌管理计划的利用和影响。

背景

T2念珠菌检测小组（T2CP）具有很高的灵敏度和特异性，可检测出念珠菌血症，使提供者能够快速做出治疗决策，并可能降低死亡率。然而，在实践和临床应用中的利用尚待评估。

目标

评估大型社区医院中T2CP的总体提供者利用情况。

方法

这项单一的中心回顾性观察研究比较了所有T2CP阳性或阴性的患者的抗真菌治疗。其他终点包括影响抗真菌治疗决策的患者特异性变量。

结果

评估了628个T2CP结果。在T2CP测试时，接受抗真菌药物治疗的患者中有54％进行了抗真菌药物优化。60.4％的阴性病例避免了抗真菌治疗。与阳性测试相比，T2CP阴性的患者的治疗天数明显减少。

结论

尽管T2CP阴性试验导致抗真菌治疗的天数减少，但仍发现了许多改善真菌管理的机会，特别是阴性试验。