Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. These unique features, as well as the role of the intracellular pool of FGF1 and FGF2, are far from being fully understood. An increasing number of reports address this problem, focusing on the intracellular interactions of FGF1 and 2. Here, we summarize the current state of knowledge of the FGF1 and FGF2 binding partners inside the cell and the possible role of these interactions. The partner proteins are grouped according to their function, including proteins involved in secretion, cell signaling, nucleocytoplasmic transport, binding and processing of nucleic acids, ATP binding, and cytoskeleton assembly. An in-depth analysis of the network of these binding partners could indicate novel, non-classical functions of FGF1 and FGF2 and uncover an additional level of a fine control of the well-known FGF-regulated cellular processes.

成纤维细胞生长因子 1 和 2（FGF1 和 FGF2）主要被认为是表面受体的配体，通过它们调节广泛的生物过程。它们以非典型方式分泌，与其他生长因子不同，它们能够从内体转移到细胞内部。这些独特的特征，以及细胞内 FGF1 和 FGF2 库的作用，还远未完全了解。越来越多的报告解决了这个问题，重点关注 FGF1 和 2 的细胞内相互作用。在这里，我们总结了细胞内 FGF1 和 FGF2 结合伙伴的当前知识状态以及这些相互作用的可能作用。伙伴蛋白根据其功能分组，包括参与分泌、细胞信号、核质转运、核酸的结合和加工、ATP 结合和细胞骨架组装。对这些结合伙伴网络的深入分析可以表明 FGF1 和 FGF2 的新的、非经典的功能，并揭示对众所周知的 FGF 调节的细胞过程的精细控制的额外水平。