Nifedipine is a calcium channel blocker widely used for the treatment of blood pressure related diseases such as angina, hypertension and Raynaud. However, since the drug after the administration reaches the highest blood concentration between 30 min and 2 h, its insolubility may expose the patient to various side effects. In this study, nifedipine was prepared as a solid dispersion using a water-soluble polymer (PVP-K30) in order to increase the releasing time and postpone the time at which the drug reaches its highest concentration, thereby increasing its bioavailability. SEM, XRD, DSC, and FT-IR were used for characterization of the solid dispersion. In order to test the release of the drug, a dissolution test was performed with a serous fluid for 12 h. In this work a drug formulation capable of sustained release of nifedipine using a water-soluble polymer was developed.

中文翻译：

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硝苯地平固体分散体与各种聚合物的缓释配方

硝苯地平是一种钙通道阻滞剂，广泛用于治疗与血压有关的疾病，如心绞痛，高血压和雷诺。但是，由于药物在给药后30分钟至2小时之间达到最高血药浓度，其不溶性可能使患者遭受各种副作用。在这项研究中，硝苯地平使用水溶性聚合物（PVP-K30）制成固体分散体，以增加释放时间并推迟药物达到最高浓度的时间，从而提高其生物利用度。SEM，XRD，DSC和FT-IR用于表征固体分散体。为了测试药物的释放，用浆液进行了12小时的溶出度测试。