Abstract “Mitochondrial transplantation” refers to a procedure for introducing isolated mitochondria into a damaged area of a heart or other organ. A considerable amount of data has been accumulated on the therapeutic effects of “mitochondrial transplantation” in animals with ischemic heart damage. In 2017, the first attempts were made to apply this procedure in a clinic. The authors of the method suggest that exogenous mitochondria penetrate into cardiomyocytes, retaining functional activity, and compensate for impaired energy output of endogenous mitochondria. This hypothesis contradicts the well-known fact of loss of mitochondrial functions in the presence of high concentrations of Ca 2+ , which are characteristic of the extracellular medium. This review critically considers the possible mechanisms of the therapeutic effect of “mitochondrial transplantation”.

中文翻译：

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线粒体移植：批判性分析

摘要 “线粒体移植”是指将分离的线粒体引入心脏或其他器官的受损区域的过程。“线粒体移植”对缺血性心脏损伤动物的治疗效果已经积累了大量数据。2017 年，首次尝试将该程序应用于诊所。该方法的作者建议外源性线粒体渗透到心肌细胞中，保留功能活性，并补偿内源性线粒体受损的能量输出。这一假设与众所周知的在高浓度 Ca 2+ 存在下线粒体功能丧失的事实相矛盾，这是细胞外介质的特征。