Introduction We investigated whether higher body mass index (BMI) may causally increase risk of carpal tunnel syndrome using Mendelian randomization (MR). Methods The exposure included genetic instruments comprising independent variants associated with BMI (n=322,154). Associations of these variants with CTS were obtained from a genome-wide association study conducted in UK Biobank (UKB; 12,312 cases/389,344 controls) with replication in the FinnGen cohort (4,505 cases/86,854 controls). Causal effects were estimated using inverse-variance weighted regression, and sensitivity analyses probed robustness of results. Results A 1-standard deviation (4.7kg/m2) increase in genetically instrumented BMI increased the odds of CTS in UKB (OR 1.73, 95% CI 1.48-2.02, P=2.68x10-12; 16.8 additional cases per 1000 person-years [95% CI 11.0-23.5]). This effect was consistent in the replication sample and across sensitivity analyses. Discussion These data support a causal effect of higher BMI on susceptibility to CTS. Clinical investigations of weight loss for treatment of CTS may be warranted.

中文翻译：

---

体重指数和腕管综合症：孟德尔随机研究

简介我们使用孟德尔随机研究（MR）调查了较高的体重指数（BMI）是否可能因果关系增加了腕管综合征的风险。方法：暴露的基因工具包括与BMI相关的独立变体（n = 322,154）。这些变体与CTS的关联是从UK Biobank（UKB； 12,312例/ 389,344对照）进行的全基因组关联研究中获得的，并在FinnGen队列中进行了复制（4,505例/ 86,854对照）。使用反方差加权回归估计因果关系，而敏感性分析则探明结果的稳健性。结果转基因BMI增加1标准差（4.7kg / m2）增加UKB中CTS的几率（OR 1.73，95％CI 1.48-2.02，P = 2.68x10-12;每1000人年新增16.8例[95％CI 11.0-23.5]。该效果在复制样品中以及在敏感性分析中均保持一致。讨论这些数据支持较高的BMI对CTS易感性的因果关系。减轻体重以治疗CTS的临床研究可能是必要的。