Lymphotoxin‐alpha (LTA), a proinflammatory cytokine, is significantly associated with the progression of atherosclerosis as an independent hazard factor for stroke. According to new genetic studies, polymorphisms in the LTA gene that influence its expression or biological function may play a role in the progress of stroke; thus, the present case–control study investigated LTA gene polymorphisms (rs909253, rs1800683 and rs2229094) and the risk of large artery atherosclerosis stroke (LAA) in an Iranian population.

中文翻译：

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伊朗人群中淋巴毒素-α 基因多态性（rs909253、rs1800683 和 rs2229094）与大动脉粥样硬化中风风险的关联。

Lymphotoxin-alpha ( LTA ) 是一种促炎细胞因子，作为卒中的独立危险因素，与动脉粥样硬化的进展显着相关。根据新的遗传学研究，影响其表达或生物学功能的LTA基因多态性可能在中风的进展中起作用；因此，本病例对照研究调查了伊朗人群中LTA基因多态性（rs909253、rs1800683 和 rs2229094）和大动脉粥样硬化中风 (LAA) 的风险。