The Beneficial Effects of Lippia Citriodora Extract on Diet-Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition.,Molecular Nutrition & Food Research

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The Beneficial Effects of Lippia Citriodora Extract on Diet-Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-02 , DOI: 10.1002/mnfr.202000005
Patricia Diez-Echave _{1,

2} , Teresa Vezza _{1,

2} , Alba Rodríguez-Nogales _{1,

2} , Laura Hidalgo-Garcia _{1,

2} , José Garrido-Mesa ₁ , Antonio Ruiz-Malagon _{1,

2} , Jose Alberto Molina-Tijeras _{1,

2} , Miguel Romero _{2,

3} , Iñaki Robles-Vera _{2,

3} , Francisco Javier Leyva-Jiménez ₄ , Jesús Lozano-Sanchez _{4,

5} , David Arráez-Román _{4,

6} , Antonio Segura-Carretero _{4,

6} , Vicente Micol _{7,

8} , Federico García _{2,

9} , Rocío Morón _{2,

10} , Juan Duarte _{2,

3} , Maria Elena Rodríguez-Cabezas _{1,

2} , Julio Gálvez _{1,

2}

Affiliation

CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, 18071, Spain.
Instituto de Investigación Biosanitaria de Granada (ibs. 18014 GRANADA), Granada, 18014, Spain.
CIBER-Enfermedades Cardiovasculares, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, 18071, Spain.
Research and Development Centre for Functional Food (CIDAF), PTS Granada, Granada, 18016, Spain.
Department of Food Science and Nutrition, University of Granada, Granada, 18071, Spain.
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, 18071, Spain.
Instituto de Biología Molecular y Celular (IBMC) and Instituto de Investigación e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (UMH), Elche, 03202, Spain.
CIBER, Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Insituto de Salud Carlos III (CB12/03/30038), Palma de Mallorca, 07122, Spain.
Clinical Microbiology Service, Hospital Universitario San Cecilio, Red de Investigación en SIDA, Granada, 18016, Spain.
Servicio Farmacia Hospitalaria, Hospital Universitario Clinico San Cecilio, Granada, 18016, Spain.

Obesity is characterized by a dysfunction in the adipose tissue and an inflammatory subclinical state leading to insulin resistance and increased risk of cardiovascular diseases. It is also associated with intestinal dysbiosis that contributes to inflammation development. Lippia citriodora (LCE) contains high levels of polyphenolpropanoids and has shown promising results in obesity. The aim of this study is to investigate a well‐characterized extract of LCE in a model of metabolic syndrome in mice, focusing on its effects on metabolic tissues, endothelial dysfunction, and microbiome.

中文翻译：

柠檬Li鱼提取物对小鼠饮食诱导的肥胖的有益作用与肠道菌群组成的调节有关。

肥胖症的特征在于脂肪组织功能障碍和炎性亚临床状态，导致胰岛素抵抗和心血管疾病风险增加。它还与导致营养不良的肠道营养不良有关。柠檬小pp（LCE）含有大量的多酚类化合物，在肥胖症中显示出令人鼓舞的结果。这项研究的目的是研究小鼠代谢综合征模型中特征明确的LCE提取物，重点研究其对代谢组织，内皮功能障碍和微生物组的影响。

更新日期：2020-06-02

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