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Sex‐dependent effects of post‐weaning exposure to an enriched environment on novel objective recognition memory and anxiety‐like behaviors: the role of hippocampal BDNF level
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-05-31 , DOI: 10.1002/jdn.10038 Nona Sakhaie 1 , Farshid Sadegzadeh 1 , Alireza Mohammadnia 2 , Masoumeh Dadkhah 3 , Hakimeh Saadati 4, 5
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-05-31 , DOI: 10.1002/jdn.10038 Nona Sakhaie 1 , Farshid Sadegzadeh 1 , Alireza Mohammadnia 2 , Masoumeh Dadkhah 3 , Hakimeh Saadati 4, 5
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Exposure to enriched environment (EE) has been indicated to enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long-term potentiation, and levels of the brain-derived neurotrophic factor (BDNF) in laboratory animals. Also, studies on the sex-dependent effects of exposure to EE during adolescence on adult cognitive functions are less. This is important since the beneficial effects of EE may be predominant in the adolescence stage. Therefore, the present study was designed to compare the effects of EE during adolescence(PND21-PND60) on novel objective recognition memory (NORM), anxiety-like behaviors and hippocampal BDNF mRNA level in the adult male and female rats. Assessment of NORM and anxiety-like behaviors has been done by novel objective recognition task, open field (OF), and elevated plus maze (EPM) respectively. The expression of BDNF mRNA level was also evaluated by quantitative RT-PCR. Our findings demonstrated that housing in the EE during adolescence improves novel objective recognition memory in adult male rats. Also, exposure to EE during adolescence had a different effect on anxiety-like behaviors in both sexes. Additionally, our results indicated an augmented BDNF level in the hippocampus of male and female rats. In conclusion, adolescent exposure to EE has sex-dependent effects on cognitive functions and anxiety-like behaviors and increases BDNF mRNA expression in the hippocampus of both male and female rats; thus, BDNF is an important factor that can mediate the beneficial effects of EE and running exercise on cognitive functions and psychiatric traits.
中文翻译：
断奶后暴露于丰富环境对新的客观识别记忆和焦虑样行为的性别依赖性影响：海马 BDNF 水平的作用
研究表明，暴露于丰富环境 (EE) 可以增强实验动物的认知功能、海马神经可塑性、神经发生、长时程增强和脑源性神经营养因子 (BDNF) 水平。此外，关于青春期接触电子电气设备对成人认知功能的性别依赖性影响的研究也较少。这一点很重要，因为 EE 的有益作用可能在青春期阶段占主导地位。因此，本研究旨在比较青春期EE（PND21-PND60）对成年雄性和雌性大鼠新客观识别记忆（NORM）、焦虑样行为和海马BDNF mRNA水平的影响。NORM 和类焦虑行为的评估分别通过新颖的客观识别任务、开放视野 (OF) 和高架十字迷宫 (EPM) 来完成。还通过定量RT-PCR评估BDNF mRNA水平的表达。我们的研究结果表明，青春期住在 EE 中可以改善成年雄性大鼠的新客观识别记忆。此外，青春期接触电子烟对两性的焦虑样行为有不同的影响。此外，我们的结果表明雄性和雌性大鼠海马体中的 BDNF 水平有所增加。总之，青少年暴露于 EE 对认知功能和焦虑样行为具有性别依赖性的影响，并增加雄性和雌性大鼠海马中 BDNF mRNA 的表达。因此，BDNF 是调节 EE 和跑步运动对认知功能和精神特征有益影响的重要因素。
更新日期：2020-05-31
中文翻译：
断奶后暴露于丰富环境对新的客观识别记忆和焦虑样行为的性别依赖性影响：海马 BDNF 水平的作用
研究表明，暴露于丰富环境 (EE) 可以增强实验动物的认知功能、海马神经可塑性、神经发生、长时程增强和脑源性神经营养因子 (BDNF) 水平。此外，关于青春期接触电子电气设备对成人认知功能的性别依赖性影响的研究也较少。这一点很重要，因为 EE 的有益作用可能在青春期阶段占主导地位。因此，本研究旨在比较青春期EE（PND21-PND60）对成年雄性和雌性大鼠新客观识别记忆（NORM）、焦虑样行为和海马BDNF mRNA水平的影响。NORM 和类焦虑行为的评估分别通过新颖的客观识别任务、开放视野 (OF) 和高架十字迷宫 (EPM) 来完成。还通过定量RT-PCR评估BDNF mRNA水平的表达。我们的研究结果表明，青春期住在 EE 中可以改善成年雄性大鼠的新客观识别记忆。此外，青春期接触电子烟对两性的焦虑样行为有不同的影响。此外，我们的结果表明雄性和雌性大鼠海马体中的 BDNF 水平有所增加。总之，青少年暴露于 EE 对认知功能和焦虑样行为具有性别依赖性的影响，并增加雄性和雌性大鼠海马中 BDNF mRNA 的表达。因此，BDNF 是调节 EE 和跑步运动对认知功能和精神特征有益影响的重要因素。
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