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Circles of Life: linking metabolic and epigenetic cycles to immunity.
Immunology ( IF 4.9 ) Pub Date : 2020-05-16 , DOI: 10.1111/imm.13207 Chan-Wang Jerry Lio 1, 2 , Stanley Ching-Cheng Huang 3, 4
Immunology ( IF 4.9 ) Pub Date : 2020-05-16 , DOI: 10.1111/imm.13207 Chan-Wang Jerry Lio 1, 2 , Stanley Ching-Cheng Huang 3, 4
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Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreography between metabolome and epigenome in the control of immune cell differentiation and function, with a major focus on histone modifications. Yet, despite its importance in gene regulation, DNA methylation and its relationship with metabolism is relatively unclear. In this review, we will describe how the metabolic flux can influence epigenetic networks in innate and adaptive immune cells, with a focus on the DNA methylation cycle and the metabolites S‐adenosylmethionine and α‐ketoglutarate. Future directions will be discussed for this rapidly emerging field.
中文翻译：
生命周期：将代谢和表观遗传周期与免疫联系起来。
代谢物是表观遗传修饰酶在细胞中书写或擦除表观遗传蓝图的必要底物。因此，营养物质的可用性和代谢途径的活性强烈影响酶的功能。最近的研究阐明了代谢组和表观基因组之间在控制免疫细胞分化和功能方面的编排，主要关注组蛋白修饰。然而，尽管它在基因调控中很重要，但 DNA 甲基化及其与代谢的关系相对不清楚。在这篇综述中，我们将描述代谢通量如何影响先天性和适应性免疫细胞的表观遗传网络，重点是 DNA 甲基化循环和代谢物S-腺苷甲硫氨酸和α-酮戊二酸。将讨论这个快速新兴领域的未来方向。
更新日期：2020-05-16
中文翻译：
生命周期：将代谢和表观遗传周期与免疫联系起来。
代谢物是表观遗传修饰酶在细胞中书写或擦除表观遗传蓝图的必要底物。因此，营养物质的可用性和代谢途径的活性强烈影响酶的功能。最近的研究阐明了代谢组和表观基因组之间在控制免疫细胞分化和功能方面的编排，主要关注组蛋白修饰。然而，尽管它在基因调控中很重要，但 DNA 甲基化及其与代谢的关系相对不清楚。在这篇综述中，我们将描述代谢通量如何影响先天性和适应性免疫细胞的表观遗传网络，重点是 DNA 甲基化循环和代谢物S-腺苷甲硫氨酸和α-酮戊二酸。将讨论这个快速新兴领域的未来方向。
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