Sodium valproate (VPA), the most effective antiepileptic drug for patients with genetic generalized epilepsy (GGE), is a potent human teratogen that increases the risk of a range of congenital malformations, including spina bifida. The mechanisms underlying this teratogenicity are not known, but may involve genetic risk factors. This study aimed to develop an animal model of VPA‐induced birth defects.

中文翻译：

---

妊娠期长期口服治疗丙戊酸盐致畸大鼠模型

丙戊酸钠 (VPA) 是治疗遗传性全身性癫痫 (GGE) 患者最有效的抗癫痫药物，是一种强效的人类致畸剂，会增加一系列先天性畸形的风险，包括脊柱裂。这种致畸性的潜在机制尚不清楚，但可能涉及遗传风险因素。本研究旨在开发 VPA 诱导的出生缺陷动物模型。