Reversal of Regioselectivity in Zinc-Dependent Medium-Chain Alcohol Dehydrogenase from Rhodococcus erythropolis toward Octanone Derivatives.,ChemBioChem

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Reversal of Regioselectivity in Zinc-Dependent Medium-Chain Alcohol Dehydrogenase from Rhodococcus erythropolis toward Octanone Derivatives.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-05-16 , DOI: 10.1002/cbic.202000247
Gaurao V Dhoke ₁ , Yunus Ensari _{1,

2} , Dinc Yasat Hacibaloglu ₁ , Anna Gärtner ₁ , Anna Joëlle Ruff ₁ , Marco Bocola ₁ , Mehdi D Davari ₁

Affiliation

Reversal of regioselectivity: A versatile ADH from R. erythropolis (ReADH) accepts only carbonyl substrates with either a methyl or ethyl group adjacent to carbonyl moiety. Modified ReADH converts bulky substrates (ethyl 2‐oxo‐4‐phenylbutyrate) and opens up a new route for the synthesis of ethyl‐2‐hydroxy‐4‐phenylbutanoate, which is an important intermediate for anti‐hypertension drugs like enalaprilat and lisinopril.

中文翻译：

从红球红球菌对锌依赖性中链醇脱氢酶向八烷酮衍生物的区域选择性逆转。

区域选择性的逆转：来自红球菌（ReADH）的多用途ADH仅接受羰基底物，该底物具有与羰基部分相邻的甲基或乙基。改良的ReADH可以转化庞大的底物（2-氧代-4-苯基丁酸乙酯），并为合成2-羟基--4-苯基丁酸乙酯开辟了一条新途径，这是抗高血压药物依那普利拉和赖诺普利的重要中间体。

更新日期：2020-05-16

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