Diagnosis and management of bipolar disorder (BD) are limited by the absence of available biomarkers. Allostatic load (AL) represents the strain that stress, including the effects of acute phases and inter‐episode chronic mood instability, exerts on interconnected biological systems. This study aimed to operationalize an AL index and explore whether it could be relevant to better characterize BD patients with and without emotional hyper‐reactivity particularly those at higher risk of immune‐cardiometabolic dysregulation and functional impairment.

中文翻译：

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双相情感障碍患者的同种异体负荷，情绪高反应性和功能。

躁郁症（BD）的诊断和管理受到缺乏可用生物标志物的限制。静态负荷（AL）表示应力，包括急性期和情节间慢性情绪不稳定性的影响，对相互连接的生物系统施加的压力。这项研究旨在操作AL指数，并探讨该指数是否可以更好地表征患有或不患有情绪高反应性的BD患者，尤其是那些免疫代谢异常和功能受损风险较高的患者。