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Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery.
Virus Research ( IF 2.5 ) Pub Date : 2020-05-16 , DOI: 10.1016/j.virusres.2020.198024
Yong-Le Yang 1 , Jia-Qi Yu 1 , Yao-Wei Huang 1
Affiliation  

Discovered in 2017, swine enteric alphacoronavirus (SeACoV), also known as swine acute diarrhea syndrome coronavirus (SADS-CoV) or porcine enteric alphacoronavirus (PEAV), is the fifth porcine CoV identified in diarrheal piglets. The presumed name "SADS-CoV" may not be appropriate since current studies have not provided strong evidence for high pathogenicity of the virus. SeACoV was the most recently recognized CoV of potential bat origin prior to the novel human severe acute respiratory syndrome CoV 2 (SARS-CoV-2), associated with the pandemic CoV disease 2019 (COVID-19). Although SeACoV is recognized as a regional epizootic virus currently, it possesses the most extensive cell species tropism in vitro among known CoVs. This review summarizes the emergence of SeACoV and updates the research progress made from 2017 to early 2020, mainly focusing on the etiology, epidemiology, evolutionary perspective, potential for interspecies transmission, pathogenesis and diagnosis.

中文翻译:

猪肠道α冠状病毒(猪急性腹泻综合征冠状病毒):发现后三年更新。

猪肠道α冠状病毒(SeACoV)(也称为猪急性腹泻综合征冠状病毒(SADS-CoV)或猪肠道α冠状病毒(PEAV))于2017年发现,是腹泻仔猪中发现的第五种猪CoV。假定名称“ SADS-CoV”可能不合适,因为当前的研究尚未提供有关病毒高致病性的有力证据。SeACoV是新的人类严重急性呼吸系统综合症CoV 2(SARS-CoV-2)之前与蝙蝠起源有关的最新蝙蝠,它与2019年大流行CoV疾病(COVID-19)有关。尽管SeACoV目前被公认为区域性流行病病毒,但在已知的CoV中,SeACoV在体外具有最广泛的细胞物种嗜性。这篇综述总结了SeACoV的出现,并更新了从2017年到2020年初的研究进展,
更新日期:2020-05-16
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