Research question

What is the fertility preservation rate among transgender women who have received professional fertility counselling compared with transgender men?

Design

This retrospective cohort study included 56 transgender women and 56 transgender men referred for comprehensive fertility counselling at the Gender Clinic of the Tel Aviv Sourasky Medical Center's Fertility Institute between January 2017 and April 2019. Statistical analyses were performed to compare transgender men with transgender women who preserved fertility and transgender people who preserved fertility and those that did not.

Results

The fertility preservation rate of transgender women was significantly higher than that of transgender men (85.7% versus 35.7%, respectively, P < 0.001). The fertility preservation rate among transgender women was associated with being older and not having undergone gender-affirming hormone (GAH) treatment. The fertility preservation rate was higher among adolescent transgender boys compared with adolescent transgender girls (35% versus 6.25%, respectively, P = 0.005). The duration of GAH treatment among the transgender men who preserved fertility was 70 months compared with 18.6 months for transgender women (P = 0.05). All transgender boys opted for oocyte cryopreservation, while half of the transgender men who had not started GAH opted for oocyte cryopreservation, and half of those who had already started on GAH opted for embryo cryopreservation.

Conclusions

High fertility preservation rates among transgender individuals were found after comprehensive fertility counselling. Fertility preservation rates among adults were higher among transgender women compared with transgender men, while the opposite was found in transgender adolescents.

中文翻译：

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与接受全面生育咨询的跨性别男性相比，跨性别女性的生育力保留率。

研究问题

与跨性别男性相比，接受专业生育咨询的跨性别女性的生育保留率如何？

设计

这项回顾性队列研究包括 2017 年 1 月至 2019 年 4 月期间在特拉维夫 Sourasky 医疗中心生育研究所性别诊所接受全面生育咨询的 56 名跨性别女性和 56 名跨性别男性。进行了统计分析以比较跨性别男性和保留了生育能力的跨性别女性生育能力和保留生育能力的变性人以及没有生育能力的人。

结果

跨性别女性的生育力保留率显着高于跨性别男性（分别为 85.7% 和 35.7%，P  < 0.001）。跨性别女性的生育能力保留率与年龄较大且未接受性别肯定激素 (GAH) 治疗有关。与青少年跨性别女孩相比，青少年跨性别男孩的生育力保留率更高（分别为 35% 和 6.25%，P  = 0.005）。保留生育能力的跨性别男性的 GAH 治疗持续时间为 70 个月，而跨性别女性为 18.6 个月（P = 0.05）。所有跨性别男孩都选择了卵母细胞冷冻保存，而没有开始 GAH 的变性男性中有一半选择了卵母细胞冷冻保存，而已经开始使用 GAH 的变性男性中有一半选择了胚胎冷冻保存。

结论

在全面的生育咨询后，发现跨性别者的生育能力保留率很高。与跨性别男性相比，跨性别女性的成年人生育能力保留率更高，而跨性别青少年则相反。