The use of photoacoustics (PA) being a convenient non-invasive analysis tool is widespread in various biomedical fields. Despite significant advances in traditional PA cell systems, detection platforms capable of providing high signal-to-noise ratios and steady operation are yet to be developed for practical micro/nano biosensing applications. Microfabricated transducers offer orders of magnitude higher quality factors and greatly enhanced performance in extremely miniature dimensions that is unattainable with large-scale PA cells. In this work we exploit these attractive attributes of microfabrication technology and describe the first implementation of a vacuum-packaged microscale resonator in photoacoustic biosensing. Steady operation of this functional approach is demonstrated by detecting the minuscule PA signals from the variations of trace amounts of glucose in gelatin-based synthetic tissues. These results demonstrate the potential of the novel approach to broad photoacoustic applications, spanning from micro-biosensing modules to the analysis of solid and liquid analytes of interest in condense mediums.

光声（PA）是一种方便的非侵入性分析工具，在各种生物医学领域中广泛使用。尽管传统的PA细胞系统取得了重大进步，但仍可为实际的微/纳米生物传感应用开发能够提供高信噪比和稳定运行的检测平台。微型换能器提供了数量级更高的品质因数，并在极其微型的尺寸中大大增强了性能，这是大型PA电池无法实现的。在这项工作中，我们利用了微制造技术的这些吸引人的特性，并描述了在光声生物传感中真空包装的微型谐振器的首次实现。通过从基于明胶的合成组织中痕量葡萄糖的变化中检测出微小的PA信号，可以证明这种功能性方法的稳定运行。这些结果证明了这种新方法在广泛的光声应用中的潜力，其范围从微生物传感模块到在浓缩介质中分析感兴趣的固体和液体分析物。