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Pathophysiological impacts of exposure to an endocrine disruptor (tetradifon) on α–amylase and lipase activities associated metabolic disorders
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.pestbp.2020.104606 Riadh Badraoui 1 , Hmed Ben-Nasr 2 , Fevzi Bardakçi 3 , Tarek Rebai 4
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.pestbp.2020.104606 Riadh Badraoui 1 , Hmed Ben-Nasr 2 , Fevzi Bardakçi 3 , Tarek Rebai 4
Affiliation
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We have investigated the effect of subchronic exposure to tetradifon (TDF), as an endocrine disruptor chemical, on some parameters related to serious metabolomic disorders such as obesity, type 2 diabetes and hyperlipidemia. TDF promoted significant increases in both duodenal and pancreatic α-amylase and lipase especially in the 12-weeks treated rats. Plasmatic glucose and lipid profile; total cholesterol (T-cholesterol), low density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c) and glyceride, were markedly disrupted. Compared with controls, biochemical liver injury parameters: aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and lactate dehydrogenase (LDH) were significantly increased. Moreover, notable pathological features were reported in liver tissues. These results confirm a strong relationship between exposure to an endocrine disruptor and metabolic disorders. In fact, subchronic exposure to TDF lead to lipidemic and glycemic disruption associated hyperactivity in both α-amylase and lipase. Overall, these disruptions could be an important step on the pathway to metabolic pathology.
中文翻译：
暴露于内分泌干扰物（四氟甲磺酸）对与代谢紊乱相关的 α-淀粉酶和脂肪酶活性的病理生理学影响
我们研究了亚慢性暴露于作为内分泌干扰物化学物质的四氟甲磺酸 (TDF) 对与严重代谢组学障碍（如肥胖、2 型糖尿病和高脂血症）相关的一些参数的影响。TDF 促进十二指肠和胰腺 α-淀粉酶和脂肪酶的显着增加，尤其是在 12 周治疗的大鼠中。血浆葡萄糖和脂质分布；总胆固醇（T-胆固醇）、低密度脂蛋白-胆固醇（LDL-c）、高密度脂蛋白-胆固醇（HDL-c）和甘油酯被显着破坏。与对照组相比，生化肝损伤参数：天冬氨酸转氨酶（ASAT）、丙氨酸转氨酶（ALAT）和乳酸脱氢酶（LDH）显着升高。此外，在肝组织中报道了显着的病理特征。这些结果证实了暴露于内分泌干扰物与代谢紊乱之间的密切关系。事实上，亚慢性暴露于 TDF 会导致与 α-淀粉酶和脂肪酶过度活跃相关的血脂和血糖紊乱。总的来说，这些破坏可能是代谢病理学途径上的重要一步。
更新日期：2020-07-01
中文翻译：
暴露于内分泌干扰物（四氟甲磺酸）对与代谢紊乱相关的 α-淀粉酶和脂肪酶活性的病理生理学影响
我们研究了亚慢性暴露于作为内分泌干扰物化学物质的四氟甲磺酸 (TDF) 对与严重代谢组学障碍（如肥胖、2 型糖尿病和高脂血症）相关的一些参数的影响。TDF 促进十二指肠和胰腺 α-淀粉酶和脂肪酶的显着增加，尤其是在 12 周治疗的大鼠中。血浆葡萄糖和脂质分布；总胆固醇（T-胆固醇）、低密度脂蛋白-胆固醇（LDL-c）、高密度脂蛋白-胆固醇（HDL-c）和甘油酯被显着破坏。与对照组相比，生化肝损伤参数：天冬氨酸转氨酶（ASAT）、丙氨酸转氨酶（ALAT）和乳酸脱氢酶（LDH）显着升高。此外，在肝组织中报道了显着的病理特征。这些结果证实了暴露于内分泌干扰物与代谢紊乱之间的密切关系。事实上，亚慢性暴露于 TDF 会导致与 α-淀粉酶和脂肪酶过度活跃相关的血脂和血糖紊乱。总的来说，这些破坏可能是代谢病理学途径上的重要一步。
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