In bone tissue engineering, the structure of a scaffold is very important for cell growth and bone regeneration. It is better to make the scaffold resemble the native cancellous bone because natural cancellous bone can promote scaffold revascularization, which then accelerates cell proliferation. This study presents a parameterized design and fabrication method for cranial scaffold construction. A native human cranial sample was first scanned using micro computed tomography (CT), followed by 3D reconstruction, after which the internal structure of the bone trabecula was created. Based on an extracted negative bone trabecula model, the design components of “cavity”, “connecting pipe” and “spatial framework” were proposed to describe the scaffold model. Then, by using the parameterized component model and an assembly and deformation algorithm, the bionic scaffold was designed. Its porous distribution, connection, porosity and area size were easily controlled. Finally, a biomaterial scaffold case was fabricated using a gelcasting process, and cell culture testing was performed in vitro to verify the scaffold's biocompatibility. The results show that the scaffold can promote cell growth and that cells accumulate in the form of a mass within three days.

在骨组织工程中，支架的结构对于细胞生长和骨再生非常重要。最好使支架类似于天然的松质骨，因为天然的松质骨可以促进支架的血运重建，从而加速细胞增殖。这项研究提出了一种参数化的设计和制造颅骨支架的方法。首先使用微型计算机断层扫描（CT）扫描人类的颅骨样本，然后进行3D重建，然后创建骨小梁的内部结构。基于提取的负骨小梁模型，提出了“腔”，“连接管”和“空间框架”的设计组件来描述支架模型。然后，通过使用参数化的零件模型以及装配和变形算法，设计了仿生支架。它的多孔分布，连接，孔隙率和面积大小易于控制。最后，使用凝胶浇铸工艺制造了生物材料支架箱，并在体外进行了细胞培养测试以验证支架的生物相容性。结果表明该支架可以促进细胞生长，并且细胞在三天内以团块的形式积累。