Effects of zinc pyrithione (ZnPT) and inorganic Zn (ZnCl₂) were evaluated on a marine polychaete at sublethal concentrations for 14 days. ZnPT decreased the burrowing activity and AChE activity with higher acute toxicities, implying its cholinergic effect. Both ZnPT and ZnCl₂ increased MDA levels at higher concentrations, suggesting lipid peroxidation and oxidative stress. In the ZnPT-treated polychaete, enzymatic activities of CAT and SOD were elevated with an increase in DNA damage, whereas the levels of GSH, GPx, GR, and GST were decreased. However, in the ZnCl₂-treated polychaete, the level of GSH and enzymatic activities of CAT, SOD, GPx, GR, and GST were significantly elevated to resist cellular damage. During 97 days depuration experiment, significant mortality and growth retardation were observed in the ZnPT-exposed polychaete. Overall, ZnPT was found to be more toxic than ZnCl₂ with the harmful impact on antioxidant defense system and DNA stability in marine polychaete.

在亚致死浓度下，在海洋多毛cha上评估巯氧吡啶锌（ZnPT）和无机锌（ZnCl ₂）的作用14天。ZnPT降低了穴位活性和AChE活性，具有较高的急性毒性，表明其胆碱能作用。ZnPT和ZnCl _2均在较高浓度下增加MDA含量，表明脂质过氧化和氧化应激。在ZnPT处理的多毛动物中，CAT和SOD的酶活性随DNA损伤的增加而升高，而GSH，GPx，GR和GST的水平则降低。但是，在ZnCl _2中经处理的多毛cha，其GSH的水平和CAT，SOD，GPx，GR和GST的酶活性显着提高以抵抗细胞损伤。在97天的净化实验中，在暴露于ZnPT的多毛cha中观察到了显着的死亡率和生长迟缓。总体而言，发现ZnPT比ZnCl ₂具有更高的毒性，对海洋多毛类动物的抗氧化防御系统和DNA稳定性具有有害影响。