INTRODUCTION AND OBJECTIVE At present, there is no hematology marker with high specificity to the diagnosis and differential diagnosis of acute ischemic stroke (AIS). How to use the existing test items to improve the diagnosis efficiency worthy of discussion. D-Dimer (DD) and fibrinogen (FIB) were the common indicators in thrombotic diseases, but D-dimer to fibrinogen ratio (D/F) in AIS has not been used in clinical practice. In this work, we focus on the evaluation of D/F. METHODS 90 AIS patients were selected as the observation group and 65 other patients without coagulation function disorder as the control group. Meanwhile, a total of 33 patients with other diseases with impaired consciousness in the same period were collected. Based on the AIS patients with or without consciousness disorder divided it into consciousness disorder group and unconsciousness disorder group. Then based on the patients with or without consciousness disorder divided it into other diseases with unconsciousness disorder group and Other diseases with lacunar cerebral infarction (LCI)and disturbance of consciousness group. then compare the differences of plasma DD, FIB and D/F between groups. RESULTS All plasma DD, FIB and D/F ratio in AIS patients were significantly higher than in other disease group (P = 0.000, P = 0.001, P = 0.000), but DD, D/F in disorders of consciousness group was significantly higher than in unconsciousness disorders group (P = 0.007, P = 0.005). The DD of the AIS with consciousness disorder group were significantly higher than that of the other disease with consciousness disorder group (P = 0.042), and the DD, D/F ratio of Other diseases with lacunar cerebral infarction and disturbance of consciousness group were significantly higher than one(P = 0.000, P = 0.003). All others are undifferentiated. CONCLUSIONS When DD, D/F ratio is high, other diseases caused by consciousness disorders are likely to be combined with infarcts, which can be used for the diagnosis and differential diagnosis of patients with different types of consciousness disorders, especially hospitalized patients.

中文翻译：

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D-二聚体与纤维蛋白原比例的潜在价值在急性缺血性卒中的诊断中。

引言与目的目前，尚无对急性缺血性中风（AIS）的诊断和鉴别诊断具有高度特异性的血液学标志物。如何利用现有的测试项目来提高诊断效率值得讨论。D-二聚体（DD）和纤维蛋白原（FIB）是血栓形成疾病的常见指标，但AIS中D-二聚体与纤维蛋白原的比率（D / F）尚未在临床实践中使用。在这项工作中，我们专注于D / F的评估。方法选择90例AIS患者作为观察组，另65例无凝血功能障碍的患者作为对照组。同时，共收集了33例同期意识障碍的其他疾病患者。根据有或没有意识障碍的AIS患者将其分为意识障碍组和无意识障碍组。然后根据有无意识障碍的患者将其分为其他无意识障碍疾病组和其他腔隙性脑梗死（LCI）和意识障碍患者。然后比较两组之间血浆DD，FIB和D / F的差异。结果AIS患者的血浆DD，FIB和D / F比值均显着高于其他疾病组（P = 0.000，P = 0.001，P = 0.000），但意识障碍组的DD，D / F值明显高于其他疾病组比无意识障碍组（P = 0.007，P = 0.005）。意识障碍组的AIS的DD明显高于其他意识障碍组的疾病（P = 0.042），其他腔隙性脑梗塞和意识障碍组的DD，D / F比显着高于1（P = 0.000，P = 0.003）。所有其他均未区分。结论当DD，D / F比率高时，其他由意识障碍引起的疾病很可能与梗死合并在一起，可用于诊断和鉴别诊断不同类型意识障碍的患者，尤其是住院患者。所有其他均未区分。结论当DD，D / F比率高时，其他由意识障碍引起的疾病很可能与梗塞合并，可用于诊断和鉴别诊断不同类型意识障碍的患者，尤其是住院患者。所有其他均未区分。结论当DD，D / F比率高时，其他由意识障碍引起的疾病很可能与梗死合并在一起，可用于诊断和鉴别诊断不同类型意识障碍的患者，尤其是住院患者。