A multicomponent reaction containing curcumin, aldehydes, malononitrile and amine was developed for the one-pot synthesis of a novel library of 4H-pyran and 1,4-dihyropyridin heterocycles incorporating curcumin moiety. The products were obtained in the presence of p-toluenesulfonic acid as catalyst in ethanol as solvent in good to excellent yields.

中文翻译：

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含有 4H-吡喃和 1,4-二氢吡啶杂环的新型姜黄素氨基腈衍生物的合成。

开发了一种包含姜黄素、醛、丙二腈和胺的多组分反应，用于一锅合成含有姜黄素部分的 4H-吡喃和 1,4-二氢吡啶杂环的新型库。在对甲苯磺酸作为催化剂的情况下，在乙醇作为溶剂的情况下，以良好至极好的收率获得产物。