PURPOSE Bone metastasis (BM) can obviously affect the quality of life of patients in colorectal cancer (CRC), and the whole management of patients with BM would be attractive in current clinical practice. METHODS A total of 52,859 patients during 2010-2015 were collected from Surveillance, Epidemiology, and End Results (SEER) database. After propensity score matching (PSM), cancer-specific survival (CCS) and overall survival (OS) with BM were adopted to assess survival probability difference. Logistic regression was used to identify risk factors for BM; COX proportion hazard regression was applied to explore prognosticators for OS in patients with BM. Subsequently, nomograms were constructed and receiver operating curves (ROCs) were used to confirm the validation of nomogram. RESULTS Three hundred and forty-two (0.65%) patients were diagnosed with synchronous BM. After PSM, 16 variables were balanced. Tumor site, histology, grade, T stage, N stage, CEA, radiochemotherapy, surgery, and liver/lung/brain metastases were associated with BM, and histology, grade, T stage, N stage, CEA, chemotherapy, surgery, and liver/lung metastases were prognosticators for BM survival. Nomograms were applied and the ROC curve proved the predictive effects. CONCLUSION CRC patients with BM have worse real-world survival. Nomogram can predict incidence of BM in CRC patients and survival among patients with BM.

中文翻译：

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线型图可预测大肠癌同步骨转移的风险和生存：基于人群的现实世界分析。

目的骨转移（BM）可以明显影响大肠癌（CRC）患者的生活质量，而对BM患者的整体管理在当前临床实践中将具有吸引力。方法从监测，流行病学和最终结果（SEER）数据库中收集了2010-2015年期间的52859例患者。在倾向评分匹配（PSM）后，采用特定于肿瘤的生存率（CCS）和总体生存率（OS）与BM评估生存率差异。Logistic回归用于确定BM的危险因素。应用COX比例风险回归分析探索BM患者OS的预后因素。随后，构造列线图，并使用接收器工作曲线（ROC）确认列线图的有效性。结果342（0。65％）患者被诊断为同步性BM。在PSM之后，平衡了16个变量。肿瘤部位，组织学，分级，T期，N期，CEA，放疗，手术和肝/肺/脑转移与BM相关，并且组织学，分级，T期，N期，CEA，化学疗法，手术和肝脏/肺转移是BM生存的预后因素。应用了诺法图，ROC曲线证明了预测效果。结论CRC合并BM的患者的真实生存率较差。Nomogram可以预测CRC患者的BM发生率以及BM患者的生存率。肝/肺转移是BM生存的预后因素。应用了诺法图，ROC曲线证明了预测效果。结论CRC合并BM的患者的真实生存率较差。Nomogram可以预测CRC患者的BM发生率以及BM患者的生存率。肝/肺转移是BM生存的预后因素。应用了诺法图，ROC曲线证明了预测效果。结论CRC合并BM的患者的真实生存率较差。Nomogram可以预测CRC患者的BM发生率以及BM患者的生存率。