Anti-cytokine autoantibodies may cause immunodeficiency and have been recently recognized as 'autoimmune phenocopies of primary immunodeficiencies' and are found in particular, but not exclusively in adult patients. By blocking the cytokine's biological function, patients with anti-cytokine autoantibodies may present with a similar clinical phenotype as the related inborn genetic disorders. So far, autoantibodies to interferon (IFN)-γ, GM-CSF, to a group of TH-17 cytokines and to IL-6 have been found to be causative or closely associated with susceptibility to infection. This review compares infectious diseases associated with anti-cytokine autoantibodies with primary immunodeficiencies affecting similar cytokines or related pathways.

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针对细胞因子的自身抗体：原发性免疫缺陷的表型？

抗细胞因子自身抗体可能引起免疫缺陷，最近被公认为是“原发性免疫缺陷的自身免疫表型”，并且特别是但不限于成年患者。通过阻断细胞因子的生物学功能，具有抗细胞因子自身抗体的患者可能表现出与相关的先天遗传疾病相似的临床表型。迄今为止，已经发现针对干扰素（IFN）-γ，GM-CSF，针对一组TH-17细胞因子和针对IL-6的自身抗体与感染的易感性成因或密切相关。这篇综述比较了与抗细胞因子自身抗体相关的感染性疾病，这些抗体具有影响相似细胞因子或相关途径的原发性免疫缺陷。