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Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses.
Heart Failure Reviews ( IF 4.5 ) Pub Date : 2020-05-16 , DOI: 10.1007/s10741-020-09965-5
Tamy Colonetti 1 , Antonio Jose Grande 2 , Marcos Cruz Amaral 2 , Laura Colonetti 1 , Maria Laura Uggioni 1 , Maria Inês da Rosa 1 , Adrian V Hernandez 3, 4 , Gary Tse 5 , Tong Liu 6 , Nitesh Nerlekar 7 , Giuseppe Biondi-Zoccai 8, 9 , Mansueto Gomes Neto 10, 11 , André Rodrigues Durães 11 , Octávio Pontes-Neto 12 , Elmiro Santos Resende 12 , Leonardo Roever 13
Affiliation  

According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) levels. We included randomized controlled trials (RCTs) comparing one exercise with another exercise or diet for the treatment to reduce EAT. We used fixed effects models for meta-analyses; effects of exercise on outcomes were described as mean differences (MD) or standardized difference of means (SMD) was used, their 95% confidence intervals (CI). Five RCTs were included (n = 299), 156 in exercise group and 143 in the control. In comparison to the control group, exercise significantly reduced EAT (SMD - 0.57, 95%CI - 0.97 to - 0.18) and waist circumference (MD - 2.95 cm, 95%CI - 4.93 to - 0.97). Exercise did not have an effect on BMI (MD - 0.23 kg/m2, 95%CI - 0.73 to 0.27), weight (MD - 0.06 kg, 95%CI - 1.46 to 1.34), or HDL (SMD 0.26, 95%CI - 0.06 to 0.57).VO2 was significantly increased by exercise (SMD 1.58, 95%CI 1.17 to 1.99). Risk of bias was high for 3 studies, and GRADE quality of evidence was very low to moderate. Exercise reduced epicardial adipose tissue and waist circumference, and did not have effect on weight, BMI, or HDL. Newer trials with better design and methods are necessary to improve the quality of the evidence. PROSPERO registration number (CRD42018096581).

中文翻译:

运动对成人心外膜脂肪组织的影响:系统评价和荟萃分析。

根据以往的流行病学研究,我们可以通过运动来减少心外膜脂肪的厚度,改善心血管危险因素,而变化可能取决于运动的形式。我们系统地回顾了已发表的研究,这些研究评估了心外膜脂肪组织 (EAT) 水平的运动干预。我们纳入了随机对照试验 (RCT),将一种运动与另一种运动或饮食进行比较以减少 EAT 的治疗。我们使用固定效应模型进行荟萃分析;运动对结果的影响被描述为使用平均差异 (MD) 或标准化平均值差异 (SMD),它们的 95% 置信区间 (CI)。包括 5 个 RCT(n = 299),运动组 156 个,对照组 143 个。与对照组相比,运动显着降低了 EAT(SMD - 0.57,95%CI - 0.97 至 - 0。18) 和腰围(MD - 2.95 厘米,95% CI - 4.93 至 - 0.97)。运动对 BMI(MD - 0.23 kg/m2,95%CI - 0.73 至 0.27)、体重(MD - 0.06 kg,95%CI - 1.46 至 1.34)或 HDL(SMD 0.26,95%CI)没有影响- 0.06 到 0.57。运动使 VO2 显着增加(SMD 1.58,95%CI 1.17 到 1.99)。3 项研究的偏倚风险较高,证据的 GRADE 质量非常低至中等。运动减少了心外膜脂肪组织和腰围,对体重、BMI 或 HDL 没有影响。需要具有更好设计和方法的新试验来提高证据质量。PROSPERO 注册号 (CRD42018096581)。或 HDL(SMD 0.26,95%CI - 0.06 至 0.57)。运动使 VO2 显着增加(SMD 1.58,95%CI 1.17 至 1.99)。3 项研究的偏倚风险较高,证据的 GRADE 质量非常低至中等。运动减少了心外膜脂肪组织和腰围,对体重、BMI 或 HDL 没有影响。需要具有更好设计和方法的新试验来提高证据质量。PROSPERO 注册号 (CRD42018096581)。或 HDL(SMD 0.26,95%CI - 0.06 至 0.57)。运动使 VO2 显着增加(SMD 1.58,95%CI 1.17 至 1.99)。3 项研究的偏倚风险较高,证据的 GRADE 质量非常低至中等。运动减少了心外膜脂肪组织和腰围,对体重、BMI 或 HDL 没有影响。需要具有更好设计和方法的新试验来提高证据质量。PROSPERO 注册号 (CRD42018096581)。需要具有更好设计和方法的新试验来提高证据质量。PROSPERO 注册号 (CRD42018096581)。需要具有更好设计和方法的新试验来提高证据质量。PROSPERO 注册号 (CRD42018096581)。
更新日期:2020-05-16
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