Microtubules are essential for intracellular transport, cell motility, spindle assembly, and chromosome segregation during cell division. Microtubule dynamics regulate the proper spindle organization and thus contribute to chromosome congression and segregation. Accumulating studies suggest that kinesin-8 motors are emerging regulators of microtubule dynamics and organizations. In this review, we provide an overview of the studies focused on kinesin-8 motors in cell division. We discuss the structures and molecular kinetics of kinesin-8 motors. We highlight the essential roles and mechanisms of kinesin-8 in the regulation of microtubule dynamics and spindle organization. We also shed light on the functions of kinesin-8 motors in chromosome movement and the spindle assembly checkpoint during the cell cycle.

中文翻译：

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Kinesin-8 马达：微管动力学和染色体运动的调节

微管对于细胞内运输、细胞运动、纺锤体组装和细胞分裂过程中的染色体分离至关重要。微管动力学调节适当的纺锤体组织，从而有助于染色体的聚集和分离。越来越多的研究表明，kinesin-8 马达是微管动力学和组织的新兴调节器。在这篇综述中，我们概述了关于细胞分裂中驱动蛋白 8 马达的研究。我们讨论了 kinesin-8 马达的结构和分子动力学。我们强调了驱动蛋白 8 在微管动力学和纺锤体组织调节中的重要作用和机制。我们还阐明了驱动蛋白 8 马达在细胞周期中染色体运动和纺锤体组装检查点中的功能。