An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR, ¹HNMR, ¹³CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).

中文翻译：

---

阿司匹林连接的顺铂衍生物的合成及其在MIL-101（Fe）上的缓释研究

由乙酰水杨酸酐和氧铂在DMF中制备与阿司匹林连接的顺铂衍生物biasplatin。以氧铂和阿司匹林酸酐为起始原料，通过羟基轴向残基的取代反应，合成了氨铂。FTIR，¹ HNMR，¹³对得到的偏铂进行了充分表征。CNMR和ESI质谱。通过将Biasplatin悬浮在DMF中并在环境温度下搅拌72小时（称为biasplatin @ MIL-101（Fe））将其截留在MIL-101（Fe）中。biasplatin和biasplatin @ MIL-101（Fe）的缓慢释放是在pH为7.20、37°C​​的PBS溶液中作为介质进行的，并通过UV-Vis分光光度计进行测量。没有加载到MIL-101（Fe）中的biasplatin的释放持续3％，而biasplatin @ MIL-101（Fe）在72小时内的释放是0.05％。与未加载到MIL-101（Fe）中的biasplatin的时间释放相比，biasplatin @ MIL-101（Fe）的显着缓慢释放仅为1％。