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Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)
Chemical Papers ( IF 2.1 ) Pub Date : 2020-02-24 , DOI: 10.1007/s11696-020-01114-4
Venansia Avelia Rosari , Witri Wahyu Lestari , Maulidan Firdaus

An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR, 1HNMR, 13CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).

中文翻译:

阿司匹林连接的顺铂衍生物的合成及其在MIL-101(Fe)上的缓释研究

由乙酰水杨酸酐和氧铂在DMF中制备与阿司匹林连接的顺铂衍生物biasplatin。以氧铂和阿司匹林酸酐为起始原料,通过羟基轴向残基的取代反应,合成了氨铂。FTIR,1 HNMR,13对得到的偏铂进行了充分表征。CNMR和ESI质谱。通过将Biasplatin悬浮在DMF中并在环境温度下搅拌72小时(称为biasplatin @ MIL-101(Fe))将其截留在MIL-101(Fe)中。biasplatin和biasplatin @ MIL-101(Fe)的缓慢释放是在pH为7.20、37°C​​的PBS溶液中作为介质进行的,并通过UV-Vis分光光度计进行测量。没有加载到MIL-101(Fe)中的biasplatin的释放持续3%,而biasplatin @ MIL-101(Fe)在72小时内的释放是0.05%。与未加载到MIL-101(Fe)中的biasplatin的时间释放相比,biasplatin @ MIL-101(Fe)的显着缓慢释放仅为1%。
更新日期:2020-02-24
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