The regioselectivity of a one-pot hydrogenation/alkylation reaction of coumarins 1a and 1b with series of alkyl halides has been elucidated as a complementary work to reaction of acylation with the same coumarins. Reaction conditions have provided formation of only C-alkylation products with good to high yield. The results from the experiments are of significant importance to predict reactivity of 3-substituted coumarins in different reaction conditions.

中文翻译：

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一锅式加氢/烷基化反应中取代的香豆素作为环境亲核试剂

已经阐明了香豆素1a和1b与一系列烷基卤化物的一锅加氢/烷基化反应的区域选择性作为与相同香豆素的酰化反应的补充工作。反应条件提供了仅形成具有良好或高产率的C-烷基化产物。实验结果对于预测3-取代香豆素在不同反应条件下的反应性具有重要意义。