OBJECTIVES Injured cognitive abilities have been reported in patients with pituitary adenoma. However, to date, few researchers have directly investigated the electrophysiological study of inhibitory control function of pituitary patients both pre- and postsurgery. Thus, this study aimed to identify the factors affecting the inhibitory control function of pituitary patients. METHODS Thirty presurgery pituitary patients were recruited and 26 patients of them completed the postsurgery follow-up. Thirty healthy people were recruited for control group. Visual Go/Nogo tasks were carried out by the patients and controls to assess the inhibitory control function before surgery and 6 months after the surgery, respectively. The function of inhibitory control was analyzed with the components of N2 and P3. RESULTS Across 3 groups, Nogo stimuli evoked larger frontal-central N2nogo and P3nogo than Go stimuli did. Furthermore, N2d of presurgery patients (-1.14 μV) and postsurgery patients(-0.61 μV) were significantly decreased compared with that of control group (-3.09 μV), F(2, 83) = 13.92, P < .01, whereas no difference was detected between pre- and postsurgery groups. There was no remarkable difference in the amplitude of P3d among the 3 groups, F(2, 83) = 0.19, P > .05. With regard to the amplitude of P3 for Go condition, The P3 amplitude of healthy group (4.38 μV) was larger than both pre- and postsurgery (1.00 μV and 3.01 μV). With regard to the amplitude of P3 for Nogo condition, The P3 amplitude of healthy group (5.25 μV) was larger than both pre- and postsurgery groups (2.35 μV and 4.18 μV). CONCLUSIONS These results indicated that presurgery patients showed the dysfunction of inhibition, due to the nerve tissue damage or brain structure alteration caused by the presurgery physical pressure from tumor and abnormal hormone levels. Postsurgery patients showed a tendency toward recovery, but there was no obvious improvement in the inhibitory control function after successful treatments.

中文翻译：

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评估垂体腺瘤经蝶手术后治疗对抑制控制功能影响的纵向前瞻性研究

目的 已有报道垂体腺瘤患者认知能力受损。然而，迄今为止，很少有研究人员直接研究垂体患者术前和术后抑制控制功能的电生理学研究。因此，本研究旨在确定影响垂体患者抑制控制功能的因素。方法招募术前垂体患者30例，其中26例完成术后随访。对照组招募了 30 名健康人。患者和对照组分别在手术前和手术后 6 个月进行 Visual Go/Nogo 任务，以评估抑制控制功能。用N2和P3的成分分析抑制控制的作用。结果在 3 组中，Nogo 刺激诱发比 Go 刺激更大的额中枢 N2nogo 和 P3nogo。此外，与对照组（-3.09 μV）相比，术前患者（-1.14 μV）和术后患者（-0.61 μV）的N2d显着降低，F(2, 83) = 13.92, P < .01，而没有在术前组和术后组之间检测到差异。3组P3d幅值无显着差异，F(2, 83) = 0.19, P > .05。围棋状态下P3波幅，健康组P3波幅（4.38 μV）均大于术前和术后（1.00 μV和3.01 μV）。Nogo组P3波幅，健康组P3波幅（5.25 μV）均大于术前组和术后组（2.35 μV和4.18 μV）。结论这些结果表明，术前患者由于肿瘤的物理压力和激素水平异常引起的神经组织损伤或脑结构改变导致术前患者表现出抑制功能障碍。术后患者呈现恢复趋势，但治疗成功后抑制控制功能无明显改善。