Pulmonary capillary hemorrhage induction by diagnostic ultrasound (DUS-PCH) was investigated with respect to the influence of the fraction of inspired oxygen (FiO₂). Sprague–Dawley rats were anesthetized with Telazol only (TO) or Telazol plus xylazine (TX), which can enhance DUS-PCH. A linear array probe (10 L, GE Vivid 7 Dimension) was used in B-mode at 7.5 MHz to expose the right lung. FiO₂ at 10%, 20%, 60% and 100% was delivered through a nose cone. On the ultrasound images, the PCH effect was observed as growing comet tail (B-line) artifacts and as subpleural consolidated segments at higher FiO₂. PCH for TO with 20% and 60% FiO₂ were significantly greater (p < 0.05) than for the 10% FiO₂. PCHs with TX at 10% and 20% FiO₂ were significantly greater (p < 0.02) than those for TO anesthesia. Added xylazine and high percentages of FiO₂ reduced PCH thresholds, but xylazine and high percentages of FiO₂ together did not lower the PCH threshold further. The lowest threshold observed, 1.4 MPa, corresponded to an in situ mechanical index of 0.5.

针对吸入氧分数 (FiO ₂ )的影响，研究了通过诊断超声 (DUS-PCH) 诱导的肺毛细血管出血。Sprague-Dawley 大鼠仅用 Telazol (TO) 或 Telazol 加甲苯噻嗪 (TX) 麻醉，这可以增强 DUS-PCH。线性阵列探头（10 L，GE Vivid 7 Dimension）用于 B 模式，频率为 7.5 MHz，以暴露右肺。10%、20%、60% 和 100% 的FiO ₂通过鼻锥输送。在超声图像上，PCH 效应被观察为不断增长的彗尾（B 线）伪影和更高 FiO _{2 的}胸膜下固结段。含 20% 和 60% FiO _{2 的}TO 的 PCH显着高于含10% FiO _{2 的}( p < 0.05). 与TX PCHS在10％和20％氧合指数₂为显著更大（p <0.02）比那些TO麻醉。添加甲苯噻嗪和高百分比的 FiO ₂降低了 PCH 阈值，但甲苯噻嗪和高百分比的 FiO ₂并没有进一步降低 PCH 阈值。观察到的最低阈值 1.4 MPa，对应于0.5 的原位机械指数。