Driven by the development of mass spectrometry (MS), omics strategies become powerful tools for comprehensive analysis of organics in water. Various separation and ionization techniques have been developed in recent years for MS based omics analysis of water to achieve better resolution, sensitivity, and throughput. Additionally, advances in computer algorithms and enlargement of online databases have enabled batch processing of massive amounts of MS data, drastically shortening analysis time and increasing compound coverage. With such improvements, omics screening of organics in water becomes feasible, leading to high throughput analysis that can tentatively identify thousands of unknowns in a single run. Targeted analysis utilizes existing information of selected compounds to narrow scan ranges, collect further data on selected analytes and quantify these target compounds. Herein, we review recent advances in MS-based omics strategies integrating nontargeted and targeted techniques for analysis of organics in water and discuss existing challenges and future trends.

在质谱（MS）的发展推动下，组学策略已成为用于全面分析水中有机物的有力工具。近年来，已开发出各种分离和电离技术，用于基于MS的水组学分析，以实现更好的分离度，灵敏度和通量。此外，计算机算法的进步和在线数据库的扩展使大量MS数据的批处理成为可能，从而大大缩短了分析时间并增加了化合物的覆盖范围。有了这些改进，就可以对水中的有机物进行组学筛查，从而进行高通量分析，从而可以一次确定数千种未知物。靶向分析利用选定化合物的现有信息来缩小扫描范围，收集有关选定分析物的进一步数据并量化这些目标化合物。本文中，我们回顾了基于MS的组学策略的最新进展，该组策略结合了用于分析水中有机物的非针对性和针对性技术，并讨论了现有挑战和未来趋势。