PURPOSE To evaluate the effects of topical castor oil application to the eyelids on ocular surface and tear film parameters in patients with blepharitis. METHODS Twenty-six participants (14 females, 12 males; mean ± SD age, 38 ± 21 years) with clinical signs of blepharitis were enrolled in a prospective, investigator-masked, randomized, paired-eye trial. A 100% cold pressed castor oil formulation (Lotus Garden Botanicals, Biddeford, ME, USA) was applied to the eyelids of one eye (randomized), twice daily for 4 weeks. Ocular surface characteristics, symptoms, and tear film parameters were assessed at baseline and day 28. RESULTS Baseline measurements did not differ between treated and control eyes (all p > 0.05). A significant reduction in OSDI symptomology score was observed following the four-week treatment period (p = 0.001). Clinical improvements in eyelid margin thickening, telangiectasia, eyelash matting, madarosis, cylindrical dandruff, and lid wiper epitheliopathy were limited to treated eyes (all p < 0.01), while greater decreases in staphylococcal and seborrheic eyelash crusting were observed in treated than control eyes (both p < 0.05). No adverse events were reported during the treatment period. CONCLUSION Topical castor oil application effected significant improvements in ocular surface signs and symptoms in patients with blepharitis. The favourable therapeutic profile would suggest that castor oil demonstrates promise as a potential treatment for blepharitis, and support further efficacy trials with longer follow up. TRIAL REGISTRATION NUMBER ACTRN12618000856213.

中文翻译：

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外用眼周蓖麻油治疗睑缘炎的随机试验。

目的评估眼睑炎患者眼睑局部应用蓖麻油对眼表和泪膜参数的影响。方法一项有眼睑炎临床体征的26名参与者（14名女性，12名男性；平均±SD年龄，38±21岁）参加了一项前瞻性，研究者掩盖的随机双眼试验。将100％冷榨蓖麻油配方（Lotus Garden Botanicals，Biddeford，ME，美国）应用于一只眼睛的眼睑（随机分配），每天两次，持续4周。在基线和第28天评估了眼表特征，症状和泪膜参数。结果基线值在治疗和对照眼之间没有差异（所有p> 0.05）。在四周的治疗期后，观察到OSDI症状评分显着降低（p = 0.001）。眼睑边缘增厚，毛细血管扩张，睫毛消散，马达加斯加，圆柱状头皮屑和眼睑擦拭子上皮病的临床改善仅限于治疗的眼睛（所有p <0.01），而与对照组相比，治疗后的葡萄球菌和脂溢性睫毛结decreases的减少更大（两者p <0.05）。在治疗期间未报告不良事件。结论局部应用蓖麻油可显着改善眼睑炎患者眼表征象和症状。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进一步的疗效试验和更长的随访时间。试用注册号ACTRN12618000856213。圆柱形头皮屑和眼睑擦拭子上皮病仅限于治疗的眼睛（所有p <0.01），而与对照组相比，治疗后的葡萄球菌和脂溢性睫毛结cru的减少更大（p <0.05）。在治疗期间未报告不良事件。结论局部应用蓖麻油可显着改善睑缘炎患者的眼表征象和症状。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进一步的疗效试验和更长的随访时间。试用注册号ACTRN12618000856213。圆柱形头皮屑和眼睑擦拭子上皮病仅限于治疗的眼睛（所有p <0.01），而与对照组相比，治疗后的葡萄球菌和脂溢性睫毛结cru的减少更大（p <0.05）。在治疗期间未报告不良事件。结论局部应用蓖麻油可显着改善眼睑炎患者眼表征象和症状。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进一步的疗效试验和更长的随访时间。试用注册号ACTRN12618000856213。与对照组相比，经治疗的葡萄球菌和脂溢性睫毛结decreases的减少幅度更大（均p <0.05）。在治疗期间未报告不良事件。结论局部应用蓖麻油可显着改善眼睑炎患者眼表征象和症状。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进一步的疗效试验和更长的随访时间。试用注册号ACTRN12618000856213。与对照组相比，经治疗的葡萄球菌和脂溢性睫毛结decreases的减少幅度更大（均p <0.05）。在治疗期间未报告不良事件。结论局部应用蓖麻油可显着改善眼睑炎患者眼表征象和症状。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进行更长时间随访的进一步疗效试验。试用注册号ACTRN12618000856213。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进行更长时间随访的进一步疗效试验。试用注册号ACTRN12618000856213。良好的治疗效果表明，蓖麻油显示出有望作为睑缘炎的潜在治疗方法，并支持进行更长时间随访的进一步疗效试验。试用注册号ACTRN12618000856213。