Due to the emergence of multi-drug resistant bacteria, and the evident limitation in therapeutic options, alternatives to combat bacterial infections have been sought. One of these is phage therapy, which is the use of bacterial viruses to kill pathogenic bacteria responsible for the infection. These viruses called bacteriophages are very abundant organisms in the world and are harmless to humans. There are several advantages in using phage therapy, especially against multi-drug resistant pathogens, which tend to be dominated by individual strains. The advantages include fewer collateral effects such as lower disturbance of gut microbiota and less antimicrobials consumption, which itself leads to reducing antibiotic resistance rates. Unfortunately, few clinical studies have been initiated in Brazil and this area is little explored in our country. This manuscript describes clinical evidence of successful phage utilization on pathogens considered a threat in Brazil, highlighting the benefits of a possible phage utilization as an important tool to combat antimicrobial resistance in our country.

由于多重耐药细菌的出现，以及治疗选择的明显限制，人们一直在寻找对抗细菌感染的替代方法。其中之一是噬菌体疗法，即使用细菌病毒杀死导致感染的病原菌。这些被称为噬菌体的病毒是世界上非常丰富的生物，对人类无害。使用噬菌体疗法有几个优点，特别是针对多药耐药病原体，这些病原体往往由单个菌株主导。优点包括较少的附带影响，例如对肠道微生物群的干扰较少和抗菌药物消耗较少，这本身会导致抗生素耐药率降低。不幸的是，在巴西开展的临床研究很少，而且在我国也很少探索这一领域。