Drug resistant bacteria affects millions worldwide and remains a serious threat to health care system. The study reports the first application of hybrid nanocomposites based on zeolitic imidazolate framework-8 (ZIF-8) with MFI structured zeolite Ti-ZSM-5 (TiZ5) and mesoporous carbon (MC). The composite was designated as TiZ5/ZIF-8 and MC/ZIF-8 was studied for antibacterial activity. Bioactive components Zn²⁺ and 2-methyl imidazole present in ZIF-8 was found to exert significant antibacterial effect on Escherchia. coli and Staphyloccocus. No other antibiotic drugs are required. For comparative purpose, Fe-BTC MOF (BTC = 1,3,5‐benzenetricarboxylate) was used as second set of nanoformulations (TiZ5/Fe-BTC and MC/Fe-BTC) but showed a lower antibacterial activity. The phase (X-ray diffraction), texture (BET surface area), coordination (DRS-UV–Vis), and morphology (TEM) was investigated. XRD showed the presence of nanosized ZIF-8 over TiZ5 and MC. Surface area calculation using N₂ adsorption isotherm showed a reduction in the micropore surface area of ZIF-8 from 1148 m²/g to 224 m²/g (80%) and an increased meso surface area from 31 m²/g to 59 m²/g (90%). The mesopore pore volume increased significantly from 0.05 cm³/g to 0.12 m²/g. MC/ZIF-8 showed similar textural modifications. FT-IR spectra and DRS-UV–Vis spectra showed distinct composite formation with TiZ5, while a weak absorption of ZIF-8 observed over MC. TEM revealed the presence of nanocomposite MC/ZIF-8 and TiZ5/ZIF-8 distributed in nanosize ranging between 25 and 50 nm. TiZ5/ZIF-8 showed the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 0.5 and 1 mg/ml, respectively against E. coli. The MIC and MBC of TiZ5/ZIF-8 against S. aureus were 1 and 2 mg/ml, respectively. MC/ZIF-8 composite had second best antibacterial activity. This study shows that ZIF-8 based composite holds a great potential against E. coli and S. aureus.

耐药细菌影响着全世界数百万人，并且仍然对医疗保健系统构成严重威胁。该研究报告了基于沸石咪唑酯骨架-8 (ZIF-8) 与 MFI 结构沸石 Ti-ZSM-5 (TiZ5) 和介孔碳 (MC) 的混合纳米复合材料的首次应用。该复合材料被命名为 TiZ5/ZIF-8，并研究了 MC/ZIF-8 的抗菌活性。 ZIF-8中的生物活性成分Zn ²⁺和2-甲基咪唑被发现对埃希氏菌具有显着的抗菌作用。大肠杆菌和葡萄球菌。不需要其他抗生素药物。出于比较目的，Fe-BTC MOF（BTC = 1,3,5-苯三甲酸）被用作第二组纳米制剂（TiZ5/Fe-BTC 和 MC/Fe-BTC），但抗菌活性较低。研究了物相（X 射线衍射）、织构（BET 表面积）、配位（DRS-UV-Vis）和形态（TEM）。 XRD 显示 TiZ5 和 MC 上存在纳米 ZIF-8。使用N ₂吸附等温线的表面积计算表明，ZIF-8的微孔表面积从1148 m ² /g减少到224 m ² /g（80%），介孔表面积从31 m ² /g增加到59 m ² /g（90%）。中孔孔容从0.05 cm ³ /g显着增加至0.12 m ² /g。 MC/ZIF-8 显示出类似的结构修饰。 FT-IR 光谱和 DRS-UV-Vis 光谱显示与 TiZ5 形成明显的复合物，而在 MC 上观察到 ZIF-8 的弱吸收。 TEM 揭示了纳米复合材料 MC/ZIF-8 和 TiZ5/ZIF-8 的存在，纳米尺寸分布在 25 至 50 nm 之间。 TiZ5/ZIF-8 对大肠杆菌的最低抑菌浓度 (MIC) 和最低杀菌浓度 (MBC) 分别为 0.5 和 1 mg/ml。 TiZ5/ZIF-8 对金黄色葡萄球菌的 MIC 和 MBC 分别为 1 和 2 mg/ml 。 MC/ZIF-8复合材料的抗菌活性位居第二。这项研究表明，基于 ZIF-8 的复合材料具有对抗大肠杆菌和金黄色葡萄球菌的巨大潜力。