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Possible modulation of nervous tension-induced oxidative stress by vitamin E
Saudi Journal of Biological Sciences Pub Date : 2020-05-15 , DOI: 10.1016/j.sjbs.2020.05.018
Noorah Saleh Al-Sowayan

Stress is an unavoidable part of human life that affects a majority of people: In 2018, 55% of Americans reported experiencing stress (Gallup Global Emotions, 2019). Various factors contribute to the emergence of nervous stress among individuals, including environmental, physical, and psychological stimuli. Physical and psychological issues arise as a result of stress, which is the subject of our research study, giving it significant practical value. Here, we have tested the possible correlation between increase in oxidation species and severe psychological issues at a community level. To understand any possible connections between these two parameters, tests were conducted on 200 rats that were divided into three general groups based on the duration of stress exposure. Each group was further divided into five smaller groups with 10–20 rats. Treatments were setup with or without vitamin E with periods of stress immobilization. Samples were then collected to conduct necessary analyses from control, experimental, and treatment groups. Immobilization stress types, i.e., acute and chronic stress, caused noticeably different physiological changes, especially with respect to nature and severity of response. Chronic stress induced different responses depending on the exposure period as well. Furthermore, vitamin E appeared to have a protective role due to its antioxidant nature, which highlights the need for investigations on oxidative stress-related disease treatment and prevention.



中文翻译:

维生素E可能调节神经张力引起的氧化应激

压力是影响大多数人的人类生活中不可避免的一部分:2018年,有55%的美国人报告说承受压力(Gallup Global Emotions,2019)。各种因素导致个体中神经紧张的出现,包括环境,身体和心理刺激。压力会导致身体和心理问题,这是我们研究的主题,具有很大的实用价值。在这里,我们测试了在社区一级氧化物种增加与严重心理问题之间的可能关联。为了了解这两个参数之间的任何可能联系,对200只大鼠进行了测试,根据其暴露的持续时间将其分为三组。每组进一步分为5组,每组10-20只。设置有或没有维生素E的治疗,并固定压力。然后从对照组,实验组和治疗组收集样品进行必要的分析。固定压力类型,即急性和慢性压力,引起明显不同的生理变化,尤其是在反应的性质和严重性方面。慢性应激也会根据暴露时间引起不同的反应。此外,维生素E由于具有抗氧化特性,因此似乎具有保护作用,这突显了需要研究与氧化应激相关的疾病的治疗和预防方法。固定压力类型,即急性和慢性压力,引起明显不同的生理变化,尤其是在反应的性质和严重性方面。慢性应激也会根据暴露时间引起不同的反应。此外,维生素E由于具有抗氧化特性,因此似乎具有保护作用,这突显了需要研究与氧化应激相关的疾病的治疗和预防方法。固定压力类型,即急性和慢性压力,引起明显不同的生理变化,尤其是在反应的性质和严重性方面。慢性应激也会根据暴露时间引起不同的反应。此外,由于维生素E具有抗氧化特性,因此似乎具有保护作用,这凸显了需要对氧化应激相关疾病的治疗和预防进行研究。

更新日期:2020-05-15
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