Despite the rise in the incidence of papillary thyroid carcinoma (PTC) during the last 30 years, the mortality rate due to PTC has remained static. One reason for this phenomenon is the indolent nature of some of the tumors that are diagnosed as PTC. A subgroup of tumors, which often exhibited such indolent behavior, was encapsulated/well-circumscribed follicular lesions that showed PTC nuclear features. Despite their indolent behavior, these tumors were managed as was any other PTC, often with total thyroidectomy and radioactive iodine (RAI) treatment. In order to prevent overtreatment of these tumors, they were recently reclassified as “non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).” Since it is proposed that NIFTP be managed in a more conservative manner, its diagnosis is now based on strict histological criteria. The genetic basis of these diagnostic criteria and the utility of molecular markers in the diagnosis of NIFTP are currently being scrutinized. The aim of this review is to discuss the events that led to the emergence of the term NIFTP, as well as its histological and molecular background.

中文翻译：

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仔细查看NIFTP。

尽管在过去30年中乳头状甲状腺癌（PTC）的发病率有所上升，但PTC导致的死亡率仍然保持不变。造成这种现象的原因之一是某些被诊断为PTC的肿瘤具有惰性。经常表现出这种惰性行为的肿瘤亚组被包囊/界限清楚的滤泡状病变，表现为PTC核特征。尽管它们的行为举止柔和，但与其他任何PTC一样，这些肿瘤的治疗方法都是全甲状腺切除和放射性碘（RAI）治疗。为了防止过度治疗这些肿瘤，最近将它们重新分类为“具有乳头状核特征的非侵入性甲状腺滤泡性肿瘤（NIFTP）”。由于建议以更保守的方式管理NIFTP，其诊断现在基于严格的组织学标准。这些诊断标准的遗传基础和分子标记物在NIFTP诊断中的用途目前正在研究中。本文的目的是讨论导致术语“ NIFTP”出现的事件及其组织学和分子背景。