Abstract

Introduction

Bone has conventionally been considered to be a passive organ that only receives external control, but according to recent findings, it has become clear that bone is an endocrine organ that actively regulates systemic metabolism through osteocalcin (OC).

Methods

We focus on the relationship between the brain and bone and summarize the effects of OC on cognitive function as well as the association between OC and improved cognitive function through exercise.

Results

The findings suggest that the decrease in OC produced by bone is responsible for the decrease in cognitive function associated with aging. Furthermore, positive effect of improving cognitive function can generally be recognized in exercise interventions conducted for healthy elderly people and those with MCI, and moderate exercise is particularly effective for dementia prevention.

Conclusion

The improving bone health with aging may exert beneficial effects on cognition.

中文翻译：

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骨与脑的相互作用：骨钙素与认知

摘要

介绍

传统上，骨骼被认为是只接受外部控制的被动器官，但根据最近的发现，骨骼是一种通过骨钙素 (OC) 主动调节全身代谢的内分泌器官，这一点已变得很清楚。

方法

我们关注大脑和骨骼之间的关系，总结 OC 对认知功能的影响以及 OC 与通过运动改善认知功能之间的关联。

结果

研究结果表明，骨骼产生的 OC 减少是与衰老相关的认知功能下降的原因。此外，在对健康老年人和 MCI 患者进行的运动干预中，通常可以认识到改善认知功能的积极作用，而适度运动对预防痴呆症特别有效。

结论

随着年龄的增长改善骨骼健康可能对认知产生有益的影响。